Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
Colin Baigent,Lisa Blackwell,Rory Collins,Jonathan Emberson,Jon Godwin,Richard Peto,Julie E. Buring,Charles H. Hennekens,Patricia M. Kearney,Tom W. Meade,Carlo Patrono,Maria Carla Roncaglioni,Alberto Zanchetti +12 more
TLDR
In primary prevention without previous disease, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds.About:
This article is published in The Lancet.The article was published on 2009-05-30 and is currently open access. It has received 2954 citations till now. The article focuses on the topics: Stroke & Aspirin.read more
Citations
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Morbidity and mortality associated with atherosclerotic peripheral artery disease: A systematic review.
TL;DR: The data show PAD patients have a high risk of all-cause and CV mortality, and imply the risk of stroke or MI is at least equivalent to the risk in patients with coronary artery disease.
Journal ArticleDOI
Antithrombotic therapy and body mass: an expert position paper of the ESC Working Group on Thrombosis
Bianca Rocca,Keith A.A. Fox,Ramzi A. Ajjan,Felicita Andreotti,Colin Baigent,Jean-Philippe Collet,Erik Lerkevang Grove,Erik Lerkevang Grove,Sigrun Halvorsen,Kurt Huber,João Morais,Carlo Patrono,Andrea Rubboli,Ingebjørg Seljeflot,Dirk Sibbing,Agneta Siegbahn,Jurriën M. ten Berg,Gemma Vilahur,Freek W.A. Verheugt,Lars Wallentin,Thomas W. Weiss,Johann Wojta,Robert F. Storey +22 more
TL;DR: Antithrombotic therapy and body mass : an expert position paper of the ESC Working Group on Thrombosis.
Journal ArticleDOI
Is Acetylsalicylic Acid a Safe and Potentially Useful Choice for Adult Patients with COVID-19 ?
Vanessa Bianconi,Francesco Violi,Francesca Fallarino,Pasquale Pignatelli,Amirhossein Sahebkar,Matteo Pirro +5 more
TL;DR: A critical appraisal of current evidence on the anti-inflammatory, antithrombotic, and antiviral effects of ASA is provided, from both a pre-clinical and a clinical perspective.
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Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention.
Farzad Masoudkabir,Nizal Sarrafzadegan,Nizal Sarrafzadegan,Carolyn C. Gotay,Andrew Ignaszewski,Andrew D. Krahn,Margot K. Davis,Christopher M. M. Franco,Arya Mani +8 more
TL;DR: This review will discuss the shared genetic and molecular factors central to CVD and cancer and how the strategies commonly used for the prevention of atherosclerotic vascular disease can be applied to cancer prevention.
Journal ArticleDOI
Aspirin for the Primary Prevention of Cardiovascular Events: A Systematic Review and Meta-Analysis Comparing Patients With and Without Diabetes
Andrew D. Calvin,Niti R. Aggarwal,Mohammad Hassan Murad,Qian Shi,Mohamed B. Elamin,Jeffrey B. Geske,M. Mercè Fernández-Balsells,Felipe N. Albuquerque,Julianna F. Lampropulos,Patricia J. Erwin,Steven A. Smith,Victor M. Montori +11 more
TL;DR: Whereas estimates of benefit among patients with diabetes remain imprecise, the analysis suggests that the relative benefit of aspirin is similar in patients with and without diabetes.
References
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
Journal ArticleDOI
Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Lennart Hansson,Alberto Zanchetti,S. George Carruthers,Björn Dahlöf,Dag Elmfeldt,Stevo Julius,Joël Ménard,Karl Heinz Rahn,Hans Wedel,Sten Westerling +9 more
TL;DR: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed.
Journal ArticleDOI
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Journal ArticleDOI
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.