Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
Colin Baigent,Lisa Blackwell,Rory Collins,Jonathan Emberson,Jon Godwin,Richard Peto,Julie E. Buring,Charles H. Hennekens,Patricia M. Kearney,Tom W. Meade,Carlo Patrono,Maria Carla Roncaglioni,Alberto Zanchetti +12 more
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TLDR
In primary prevention without previous disease, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds.About:
This article is published in The Lancet.The article was published on 2009-05-30 and is currently open access. It has received 2954 citations till now. The article focuses on the topics: Stroke & Aspirin.read more
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ACG Clinical Guideline: Management of Patients With Acute Lower Gastrointestinal Bleeding
Lisa L. Strate,Ian M. Gralnek +1 more
TL;DR: In this article, the authors provided recommendations for the management of patients with acute overt lower gastrointestinal bleeding, where they assessed the patients' hemodynamic status with intravascular volume resuscitation started as needed.
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Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelines
Andrew Veitch,Geoffroy Vanbiervliet,Anthony H. Gershlick,Christian Boustière,Trevor Baglin,Lesley-Ann Smith,Franco Radaelli,Evelyn Knight,Ian M. Gralnek,Ian M. Gralnek,Cesare Hassan,Jean-Marc Dumonceau +11 more
TL;DR: The risk of endoscopy in patients on antithrombotics depends on the risks of procedural haemorrhage versus thrombosis due to discontinuation of therapy.
Journal ArticleDOI
Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses
TL;DR: The increment of improvement by drug over placebo must be viewed in the context of the disease's seriousness, suffering induced, natural course, duration, outcomes, adverse events and societal values.
Journal ArticleDOI
Effect of Aspirin on Disability-free Survival in the Healthy Elderly
John J McNeil,Robyn L. Woods,Mark Nelson,Christopher M. Reid,Brenda Kirpach,Rory Wolfe,Elsdon Storey,Raj C. Shah,Jessica E. Lockery,Andrew Tonkin,Anne B. Newman,Jeff D. Williamson,Karen L. Margolis,Michael E. Ernst,Walter P. Abhayaratna,Nigel Stocks,Sharyn M. Fitzgerald,Suzanne G Orchard,Ruth E Trevaks,Lawrence J. Beilin,Geoffrey A. Donnan,Peter Gibbs,Colin I. Johnston,Joanne Ryan,Barbara Radziszewska,Richard H. Grimm,Anne M. Murray +26 more
TL;DR: Aspirin use in healthy elderly persons did not prolong disability‐free survival over a period of 5 years but led to a higher rate of major hemorrhage than placebo.
Journal ArticleDOI
Health Disparities in Endocrine Disorders: Biological, Clinical, and Nonclinical Factors—An Endocrine Society Scientific Statement
Sherita Hill Golden,Arleen F. Brown,Jane A. Cauley,Marshall H. Chin,Tiffany L. Gary-Webb,Catherine Kim,Julie Ann Sosa,Anne E. Sumner,Blair Anton +8 more
TL;DR: Several themes emerged in the statement, including a need for basic science, population-based, translational and health services studies to explore underlying mechanisms contributing to endocrine health disparities, suggesting that population interventions targeting weight loss may favorably impact a number of endocrine disorders.
References
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
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Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Lennart Hansson,Alberto Zanchetti,S. George Carruthers,Björn Dahlöf,Dag Elmfeldt,Stevo Julius,Joël Ménard,Karl Heinz Rahn,Hans Wedel,Sten Westerling +9 more
TL;DR: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed.
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Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Journal ArticleDOI
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.