Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
Colin Baigent,Lisa Blackwell,Rory Collins,Jonathan Emberson,Jon Godwin,Richard Peto,Julie E. Buring,Charles H. Hennekens,Patricia M. Kearney,Tom W. Meade,Carlo Patrono,Maria Carla Roncaglioni,Alberto Zanchetti +12 more
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TLDR
In primary prevention without previous disease, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds.About:
This article is published in The Lancet.The article was published on 2009-05-30 and is currently open access. It has received 2954 citations till now. The article focuses on the topics: Stroke & Aspirin.read more
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Antithrombotic drugs and risk of hemorrhagic stroke in the general population
Luis A. García-Rodríguez,David Gaist,Jonathan C. Morton,Charlotte Cookson,Antonio González-Pérez +4 more
TL;DR: Chronic low-dose aspirin treatment may have a protective effect on the risk of SAH, and warfarin users in this study cohort were at a much higher risk of ICH than those receiving no therapy, with a marked association with international normalized ratio >3.
Journal ArticleDOI
Gastrointestinal effects of aspirin.
Carlos Sostres,Angel Lanas +1 more
TL;DR: There is growing evidence that long-term use of aspirin decreases the risk of colorectal cancer, even at low doses and physicians need to consider the benefits and harms for each individual patient in order to maximize the benefits of aspirin.
Journal ArticleDOI
Historical perspective and future directions in platelet research.
TL;DR: It is appropriate to consider it a Golden Age of Platelet Research and to recognize all of the investigators who have made important contributions to this remarkable achievement.
Journal ArticleDOI
Association of Antithrombotic Drug Use With Subdural Hematoma Risk
David Gaist,Luis A. García Rodríguez,Maja Hellfritzsch,Frantz Rom Poulsen,Bo Halle,Jesper Hallas,Anton Pottegård +6 more
TL;DR: In Denmark, antithrombotic drug use was associated with higher risk of subdural hematoma and was highest when a VKA was used concurrently with an antiplatelet drug.
Journal ArticleDOI
Aspirin Use to Prevent Cardiovascular Disease: US Preventive Services Task Force Recommendation Statement.
Karina W. Davidson,Michael J. Barry,Carol M. Mangione,Michael Raymond Cabana,David Chelmow,Tumaini R. Coker,Esa M. Davis,Katrina E Donahue,Carlos Roberto Jaén,Alex H. Krist,Martha Kubik,Li Li,Gbenga Ogedegbe,Lori Pbert,John M. Ruiz,James J. Stevermer,Chien-Wen Tseng,John B. Wong +17 more
TL;DR: A systematic review on the effectiveness of aspirin to reduce the risk of CVD events, cardiovascular mortality, and all-cause mortality in persons without a history of CVB concludes with moderate certainty that initiating aspirin use for the primary prevention of CVC events in adults 60 years or older has no net benefit.
References
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
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Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Lennart Hansson,Alberto Zanchetti,S. George Carruthers,Björn Dahlöf,Dag Elmfeldt,Stevo Julius,Joël Ménard,Karl Heinz Rahn,Hans Wedel,Sten Westerling +9 more
TL;DR: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed.
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Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Journal ArticleDOI
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.