Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
Colin Baigent,Lisa Blackwell,Rory Collins,Jonathan Emberson,Jon Godwin,Richard Peto,Julie E. Buring,Charles H. Hennekens,Patricia M. Kearney,Tom W. Meade,Carlo Patrono,Maria Carla Roncaglioni,Alberto Zanchetti +12 more
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TLDR
In primary prevention without previous disease, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds.About:
This article is published in The Lancet.The article was published on 2009-05-30 and is currently open access. It has received 2954 citations till now. The article focuses on the topics: Stroke & Aspirin.read more
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Clinical trials update from the European Society of Cardiology Meeting 2009: AAA, RELY, PROTECT, ACTIVE-I, European CRT survey, German pre-SCD II registry, and MADIT-CRT
TL;DR: This article provides information and a commentary on trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the annual meeting of the European Society of Cardiology held in Barcelona in 2009.
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Dental extractions and risk of bleeding in patients taking single and dual antiplatelet treatment
TL;DR: Patients taking single or dual antiplatelet drugs may have teeth extracted safely without interruption of treatment using only local haemostatic measures, and bleeding was recorded after extraction in only one patient on dual aspirin-clopidogrel treatment, which was mild and easily controlled by localHaemostasis.
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Острый коронарный синдром без подъема сегмента ST электрокардиограммы. Клинические рекомендации 2020
Olga Barbarash,Dmitry V. Duplyakov,D. A. Zateischikov,Panchenko Ep,R. M. Shakhnovich,I. S. Yavelov,A. N. Yakovlev,S. A. Abugov,B. G. Alekyan,M. V. Arkhipov,E. Yu. Vasilieva,A. S. Galyavich,Vladimir I. Ganyukov,S. R. Gilyarevskyi,E. P. Golubev,E. Z. Golukhova,N. A. Gratsiansky,Yu. A. Karpov,E. D. Kosmacheva,Yu. M. Lopatin,V. A. Markov,N. N. Nikulina,D. V. Pevzner,N. V. Pogosova,A. V. Protopopov,Dmitry Skrypnik,Tereshchenko Sn,S. A. Ustyugov,A. V. Khripun,S. V. Shalaev,V. A. Shpektor,S. S. Yakushin +31 more
TL;DR: Endorsed by: Research and Practical Council of the Ministry of Health of the Russian Federation.
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Benefit of cilostazol in patients with high risk of bleeding: subanalysis of cilostazol stroke prevention study 2.
Shinichiro Uchiyama,Yukito Shinohara,Yasuo Katayama,Takenori Yamaguchi,Shunnosuke Handa,Kempei Matsuoka,Yasuo Ohashi,Norio Tanahashi,Hiroko Yamamoto,Chokoh Genka,Yasuhisa Kitagawa,Hideo Kusuoka,Katsuya Nishimaru,Motoo Tsushima,Yukihiro Koretsune,Tohru Sawada,Chikuma Hamada +16 more
TL;DR: Hemorrhagic stroke was less frequent in the cilostazol group than in the aspirin group among patients with lacunar stroke as well as those with increased blood pressure levels, especially in these subgroups with high risks for hemorrhagic events.
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Platelets Are at the Nexus of Vascular Diseases.
TL;DR: This review will provide a comprehensive overview of platelet mechanisms involved in several vascular diseases and provide new lines of safe treatments in thrombo-inflammatory diseases.
References
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
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Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Lennart Hansson,Alberto Zanchetti,S. George Carruthers,Björn Dahlöf,Dag Elmfeldt,Stevo Julius,Joël Ménard,Karl Heinz Rahn,Hans Wedel,Sten Westerling +9 more
TL;DR: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed.
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Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
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Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.