Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program
Arthur L. Shaffer,Kuo-I Lin,Tracy C. Kuo,Xin Yu,Elaine M. Hurt,Andreas Rosenwald,Jena M. Giltnane,Liming Yang,Hong Zhao,Kathryn Calame,Louis M. Staudt +10 more
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TLDR
These findings suggest that Blimp-1 promotes plasmacytic differentiation by extinguishing gene expression important for B cell receptor signaling, germinal center B cell function, and proliferation while allowing expression of important plasma cell genes such as XBP-1.About:
This article is published in Immunity.The article was published on 2002-07-01 and is currently open access. It has received 1013 citations till now. The article focuses on the topics: Plasma cell differentiation & Cellular differentiation.read more
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Journal ArticleDOI
Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis.
Ting Fang Tang,Yee Teng Chan,Heng Choon Cheong,Yi Ying Cheok,Nur Adila Anuar,Chung Yeng Looi,Gin Gin Gan,Won Fen Wong +7 more
TL;DR: The interplay between three hallmark transcriptional regulators, IRF4, BLIMP1, and XBP1, is critical for supporting the cellular reprograming activities during B to plasma cell transition as discussed by the authors .
Book ChapterDOI
B-Cell Development
TL;DR: This article highlights the mechanisms controlling the development of B-lineage progenitors up to the fate of newly formed (NF) B cells and includes a description of how self-reactive cells are negatively regulated, and how B cells are positively selected to enter one of several functionally distinct B-cell subpopulations.
Journal ArticleDOI
SLy2-overexpression impairs B-cell development in the bone marrow and the IgG response towards pneumococcal conjugate-vaccine
TL;DR: In this article, the authors evaluated adaptive B-cell responses towards the thymus-dependent vaccine PCV13 in SLy2-overexpressing mice and to study their survival rate during pneumococcal lung infection.
Journal ArticleDOI
Exploring novel functions of BACH2 in the acquisition of antigen-specific antibodies.
Kyoko Ochiai,Kazuhiko Igarashi +1 more
TL;DR: In this paper , the authors focus on BACH2 function in B cells and reveal new functions, such as those in gene activation, that contribute to preventing the onset of human immune deficiencies.
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