Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program
Arthur L. Shaffer,Kuo-I Lin,Tracy C. Kuo,Xin Yu,Elaine M. Hurt,Andreas Rosenwald,Jena M. Giltnane,Liming Yang,Hong Zhao,Kathryn Calame,Louis M. Staudt +10 more
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TLDR
These findings suggest that Blimp-1 promotes plasmacytic differentiation by extinguishing gene expression important for B cell receptor signaling, germinal center B cell function, and proliferation while allowing expression of important plasma cell genes such as XBP-1.About:
This article is published in Immunity.The article was published on 2002-07-01 and is currently open access. It has received 1013 citations till now. The article focuses on the topics: Plasma cell differentiation & Cellular differentiation.read more
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Journal ArticleDOI
Somatic stem cells and the origin of cancer.
TL;DR: Adult stem cells are those that show long-term replicative potential, together with the capacities of self-renewal and multi-lineage differentiation, and these stem cell properties are tightly regulated in normal development, yet their alteration may be a critical issue for tumorigenesis.
Journal ArticleDOI
Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network
TL;DR: Bach2 represses many genes in T cells, including Prdm1, suggesting that the Bach2‐Prdm1 pathway is also important in maintaining the homeostasis of T cells.
Journal ArticleDOI
Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge.
Pascal Blanc,Ludovic Moro-Sibilot,Lucas Barthly,Ferdinand Jagot,Sébastien This,Simon de Bernard,Laurent Buffat,Sébastien Dussurgey,Renaud Colisson,Elias Hobeika,Thierry Fest,Morgan Taillardet,Olivier Thaunat,Antoine Sicard,Paul Mondière,Laurent Genestier,Stephen L. Nutt,Stephen L. Nutt,Thierry Defrance +18 more
TL;DR: It is shown that the nature of the secreted Ig isotype, rather than the chemical structure of the immunizing antigen, defines two functionally distinct populations of plasma cells.
Book ChapterDOI
The role of activation-induced deaminase in antibody diversification and chromosome translocations.
Almudena R. Ramiro,Bernardo Reina San-Martin,Kevin M. McBride,Mila Jankovic,Vasco M. Barreto,André Nussenzweig,Michel C. Nussenzweig,Michel C. Nussenzweig +7 more
TL;DR: How the B-cell specific molecular events required for immunoglobulin class switch recombination are initiated and how they contribute to chromosome translocations in vivo are reviewed are reviewed.
Journal ArticleDOI
Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity
Marianne Burbage,Selina Jessica Keppler,Francesca Gasparrini,Nuria Martinez-Martin,Mauro Gaya,Christoph Feest,Marie-Charlotte Domart,Cord Brakebusch,Lucy M. Collinson,Andreas Bruckbauer,Facundo D. Batista +10 more
TL;DR: Loss of Cdc42 results in aberrant B cell development, plasma cell differentiation, antigen presentation, and cellular interactions between B and T lymphocytes in vivo, which led to notable functional defects in antiviral humoral immunity.
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