Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program
Arthur L. Shaffer,Kuo-I Lin,Tracy C. Kuo,Xin Yu,Elaine M. Hurt,Andreas Rosenwald,Jena M. Giltnane,Liming Yang,Hong Zhao,Kathryn Calame,Louis M. Staudt +10 more
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TLDR
These findings suggest that Blimp-1 promotes plasmacytic differentiation by extinguishing gene expression important for B cell receptor signaling, germinal center B cell function, and proliferation while allowing expression of important plasma cell genes such as XBP-1.About:
This article is published in Immunity.The article was published on 2002-07-01 and is currently open access. It has received 1013 citations till now. The article focuses on the topics: Plasma cell differentiation & Cellular differentiation.read more
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Putting J Chain Back on the Map: How Might Its Expression Define Plasma Cell Development?
TL;DR: J chain is discussed in light of the various proposed models of its expression and regulation, with an added focus on its evolutionary significance, as well as its expression in different B cell lineages/differentiation states.
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Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome
Barbara Cassani,Pietro Luigi Poliani,Veronica Marrella,Francesca Schena,Aisha V. Sauer,Maria Ravanini,Dario Strina,Christian E. Busse,Stephan Regenass,Hedda Wardemann,Alberto Martini,Fabio Facchetti,Mirjam van der Burg,Antonius G. Rolink,Paolo Vezzoni,Fabio Grassi,Elisabetta Traggiai,Anna Villa +17 more
TL;DR: The detection of plasma cells in lymphoid organs of OS patients, in which circulating B cells are undetectable, highlights a role for B cells in OS pathogenesis and hypothesizes that impaired B cell receptor editing and a serum B cell activating factor (BAFF) abundance might contribute toward the development of a pathogenic B cell repertoire in hypomorphic Rag2R229Q knock-in mice.
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Absence of the Transcriptional Repressor Blimp-1 in Hematopoietic Lineages Reveals Its Role in Dendritic Cell Homeostatic Development and Function
Yueh-Hsuan Chan,Ming-Feng Chiang,Yueh-Chiao Tsai,Shin-Tang Su,Ming-Hsu Chen,Mau-Sheng Hou,Kuo-I Lin +6 more
TL;DR: Findings reveal two new roles for Blimp-1: negative regulation of a select subset of cDCs during homeostatic development, and enhancement of DC maturation.
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Functional Analysis of Histone Methyltransferase G9a in B and T Lymphocytes
Lance R. Thomas,Hiroki Miyashita,Robin Milley Cobb,Steven Pierce,Makoto Tachibana,Elias Hobeika,Michael Reth,Yoichi Shinkai,Eugene M. Oltz +8 more
TL;DR: Findings indicate that the H3K9me2 epigenetic mark affects a highly restricted set of processes during lymphocyte development and activation.
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Endoplasmic reticulum stress and the making of a professional secretory cell
Eelco van Anken,Ineke Braakman +1 more
TL;DR: Together, these pathways are integrated into a complex circuitry that can be modulated in various ways, not only to cope with various stress conditions, but also to fine-tune the capacity of the ER folding machinery when precursor cells differentiate into professional secretory cells.
References
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