Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program
Arthur L. Shaffer,Kuo-I Lin,Tracy C. Kuo,Xin Yu,Elaine M. Hurt,Andreas Rosenwald,Jena M. Giltnane,Liming Yang,Hong Zhao,Kathryn Calame,Louis M. Staudt +10 more
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TLDR
These findings suggest that Blimp-1 promotes plasmacytic differentiation by extinguishing gene expression important for B cell receptor signaling, germinal center B cell function, and proliferation while allowing expression of important plasma cell genes such as XBP-1.About:
This article is published in Immunity.The article was published on 2002-07-01 and is currently open access. It has received 1013 citations till now. The article focuses on the topics: Plasma cell differentiation & Cellular differentiation.read more
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Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes
Joanne Boldison,Jessica R. Hopkinson,Joanne Davies,James A. Pearson,Pia Leete,Sarah J. Richardson,Noel G. Morgan,F. Susan Wong +7 more
TL;DR: In this paper , gene expression profiling of B cell subsets identified in inflamed pancreatic tissue to explore their primary functional role during the progression of type 1 diabetes was performed on FACS-sorted B cells.
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Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma
Yandan Yang,Thomas Oellerich,Ping Chen,Arnold Bolomsky,Michele Ceribelli,Björn Häupl,George E. Wright,James D. Phelan,Da-Wei Huang,James W. Lord,Callie K. Van Winkle,Xin Yu,Jan Wisnieski,James Q. Wang,Frances A. Tosto,Erin S Beck,Kelli M. Wilson,Crystal McKnight,Jameson Travers,Carleen Klumpp-Thomas,Grace Smith,Stefania Pittaluga,Irina Maric,Dickran Kazandjian,Craig J. Thomas,Ryan M. Young +25 more
TL;DR: In this article, the authors employed an unbiased proteogenomic approach to dissect RAS signaling in multiple myeloma (MM) by combining genome-wide CRISPR-Cas9 screening with quantitative mass spectrometry focused on RAS biology, and discovered that mutant isoforms of RAS organized a signaling complex with the amino acid transporter, SLC3A2, and MTOR on endolysosomes, which directly activated mTORC1 by co-opting amino acid sensing pathways.
Dissertation
Array-comparative genomic hybridization study in diffuse large B-cell lymphoma
TL;DR: Genomic profiling of samples, identified genetic aberrations and clusters, associated with a distinct outcome in DLBCL patients, and identified a new gain, occurring at 11q24.3, containing two transcription factors, ETS1 and FLI1, indicating a role of the two genes inDLBCL pathogenesis.
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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
Marcella Calfon,Huiqing Zeng,Fumihiko Urano,Jeffery H. Till,Stevan R. Hubbard,Heather P. Harding,Scott G. Clark,David Ron +7 more
TL;DR: It is demonstrated that mutations in either ire-1 or the transcription-factor-encoding xbp-1 gene abolished the UPR in Caenorhabditis elegans, suggesting that physiological ER load regulates a developmental decision in higher eukaryotes.
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c-Myc target genes involved in cell growth, apoptosis, and metabolism
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