Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program
Arthur L. Shaffer,Kuo-I Lin,Tracy C. Kuo,Xin Yu,Elaine M. Hurt,Andreas Rosenwald,Jena M. Giltnane,Liming Yang,Hong Zhao,Kathryn Calame,Louis M. Staudt +10 more
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TLDR
These findings suggest that Blimp-1 promotes plasmacytic differentiation by extinguishing gene expression important for B cell receptor signaling, germinal center B cell function, and proliferation while allowing expression of important plasma cell genes such as XBP-1.About:
This article is published in Immunity.The article was published on 2002-07-01 and is currently open access. It has received 1013 citations till now. The article focuses on the topics: Plasma cell differentiation & Cellular differentiation.read more
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Journal ArticleDOI
The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL
Weimin Ci,Jose M. Polo,Leandro Cerchietti,Rita Shaknovich,Ling Wang,Shao Ning Yang,Kenny Ye,Pedro Farinha,Douglas E. Horsman,Randy D. Gascoyne,Olivier Elemento,Ari Melnick +11 more
TL;DR: BCL6 consensus sequence and binding sites for other physiologically relevant transcription factors were highly enriched among target genes and distributed in a pathway-dependent manner, suggesting that BCL6 forms specific regulatory circuits with other B-cell transcriptional factors.
Book ChapterDOI
Pax5: A Master Regulator of B Cell Development and Leukemogenesis
TL;DR: Pax5 controls the identity of B lymphocytes throughout B cell development, and conditional loss of Pax5 allows mature B cells from peripheral lymphoid organs to develop into functional T cells in the thymus via dedifferentiation to uncommitted progenitors in the bone marrow.
Journal ArticleDOI
Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation.
Karin Tarte,Fenghuang Zhan,Fenghuang Zhan,John De Vos,John De Vos,Bernard Klein,Bernard Klein,John D. Shaughnessy,John D. Shaughnessy +8 more
TL;DR: Data from an in vitro model making it possible to obtain a large number of cells with the morphologic, phenotypic, and functional characteristics of normal polyclonal plasmablastic cells should help to better understand the molecular events that regulate commitment to a PC fate, mediate PC maintenance in survival niches, and could facilitate PC immortalization in plasma cell dyscrasias.
Journal ArticleDOI
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
Marieta Caganova,Chiara Carrisi,Gabriele Varano,Federica Mainoldi,Federica Zanardi,Pierre-Luc Germain,Laura A. George,Federica Alberghini,Luca Ferrarini,Asoke K. Talukder,Maurilio Ponzoni,Giuseppe Testa,Takuya Nojima,Claudio Doglioni,Daisuke Kitamura,Kai-M. Toellner,I-hsin Su,Stefano Casola +17 more
TL;DR: It is shown that Ezh2 inactivation in mouse GC B cells caused profound impairment of GC responses, memory B cell formation, and humoral immunity and identifies EZH2 as a possible therapeutic target in NHL and other GC-derived B cell diseases.
Journal ArticleDOI
B cell depletion therapies in autoimmune disease: advances and mechanistic insights
TL;DR: The understanding of B cell biology is updated, the results of clinical trials using BCDT in autoimmune indications are reviewed, hypotheses for the mechanism of action are discussed, and evolving strategies for targeting B cells beyond depletion are speculated on.
References
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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
Marcella Calfon,Huiqing Zeng,Fumihiko Urano,Jeffery H. Till,Stevan R. Hubbard,Heather P. Harding,Scott G. Clark,David Ron +7 more
TL;DR: It is demonstrated that mutations in either ire-1 or the transcription-factor-encoding xbp-1 gene abolished the UPR in Caenorhabditis elegans, suggesting that physiological ER load regulates a developmental decision in higher eukaryotes.
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