Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program
Arthur L. Shaffer,Kuo-I Lin,Tracy C. Kuo,Xin Yu,Elaine M. Hurt,Andreas Rosenwald,Jena M. Giltnane,Liming Yang,Hong Zhao,Kathryn Calame,Louis M. Staudt +10 more
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TLDR
These findings suggest that Blimp-1 promotes plasmacytic differentiation by extinguishing gene expression important for B cell receptor signaling, germinal center B cell function, and proliferation while allowing expression of important plasma cell genes such as XBP-1.About:
This article is published in Immunity.The article was published on 2002-07-01 and is currently open access. It has received 1013 citations till now. The article focuses on the topics: Plasma cell differentiation & Cellular differentiation.read more
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Patent
Inducible expression systems
Benjamin Berkhout,Atze T. Das +1 more
TL;DR: In this article, the improved rtTA and single chain RtTA variants and uses thereof for inducible expression of a nucleic acid of interest are described. And vectors, replicons and cells are also provided.
Book ChapterDOI
Blimp1: driving terminal differentiation to a T.
TL;DR: Mounting evidence suggests that Blimp1 plays a common role in the terminal differentiation of multiple cell subsets in the adaptive immune system.
Journal ArticleDOI
ZFP36L1 negatively regulates plasmacytoid differentiation of BCL1 cells by targeting BLIMP1 mRNA.
Asghar Nasir,John D. Norton,Maria Baou,Anna Zekavati,Marie-José Bijlmakers,Steve Thompson,John J. Murphy,John J. Murphy +7 more
TL;DR: It is shown that ZFP36L1 expression is largely extinguished during the transition from B cells to plasma cells, in a reciprocal pattern to that of ZFP 36 and the plasma cell transcription factor, BLIMP1.
Journal ArticleDOI
Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4.
Kyoko Ochiai,Mari Yamaoka,Amrutha Swaminathan,Hiroki Shima,Hitoshi Hiura,Mitsuyo Matsumoto,Daisuke Kurotaki,Jun Nakabayashi,Ryo Funayama,Keiko Nakayama,Takahiro Arima,Tomokatsu Ikawa,Tomohiko Tamura,Roger Sciammas,Philippe Bouvet,Tapas K. Kundu,Kazuhiko Igarashi +16 more
TL;DR: In this article, the chromatin protein positive coactivator 4 (PC4) has multiple functions, including chromatin compaction, and its role in immune cells is largely unknown.
Book ChapterDOI
Signaling control of antibody isotype switching.
Zhangguo Chen,Jing Wang +1 more
TL;DR: How signals emanating from different receptors positively or negatively regulate AID expression and CSR is discussed, which is important for mediating effective humoral immunity.
References
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Journal ArticleDOI
Cluster analysis and display of genome-wide expression patterns
TL;DR: A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression, finding in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes of known similar function.
Journal ArticleDOI
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Ash A. Alizadeh,Michael B. Eisen,R. Eric Davis,Izidore S. Lossos,Andreas Rosenwald,Jennifer C. Boldrick,Hajeer Sabet,Truc Tran,Xin Yu,John Powell,Liming Yang,Gerald E. Marti,Troy Moore,James I. Hudson,Li-Sheng Lu,David B. Lewis,Robert Tibshirani,Gavin Sherlock,Wing C. Chan,Timothy C. Greiner,Dennis D. Weisenburger,James O. Armitage,Roger A. Warnke,Ronald Levy,Wyndham H. Wilson,M. R. Grever,John C. Byrd,David Botstein,Patrick O. Brown,Louis M. Staudt +29 more
TL;DR: It is shown that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour.
Journal ArticleDOI
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
Masamichi Muramatsu,Kazuo Kinoshita,Sidonia Fagarasan,Shuichi Yamada,Yoichi Shinkai,Tasuku Honjo +5 more
TL;DR: Results suggest that AID may be involved in regulation or catalysis of the DNA modification step of both class switching and somatic hypermutation in CH12F3-2 B lymphoma.
Journal ArticleDOI
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
Marcella Calfon,Huiqing Zeng,Fumihiko Urano,Jeffery H. Till,Stevan R. Hubbard,Heather P. Harding,Scott G. Clark,David Ron +7 more
TL;DR: It is demonstrated that mutations in either ire-1 or the transcription-factor-encoding xbp-1 gene abolished the UPR in Caenorhabditis elegans, suggesting that physiological ER load regulates a developmental decision in higher eukaryotes.
Journal ArticleDOI
c-Myc target genes involved in cell growth, apoptosis, and metabolism
TL;DR: The c-myc gene was discovered as the cellular homolog of the retroviral v- myc oncogene 20 years ago and found to be activated in various animal and human tumors, suggesting that it is critical for development.