Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm,Ryan W. Grant,Laura R. McCabe,Diana C. Albarado,Kim Y. Nguyen,Anthony Ravussin,Paul J. Pistell,Susan Newman,Renee T. Carter,Amanda Laque,Heike Münzberg,Clifford J. Rosen,Donald K. Ingram,J. Michael Salbaum,Vishwa Deep Dixit,Vishwa Deep Dixit +15 more
TLDR
Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.About:
This article is published in Cell Metabolism.The article was published on 2013-10-01 and is currently open access. It has received 469 citations till now. The article focuses on the topics: Inflammasome & Systemic inflammation.read more
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Book ChapterDOI
Anti-inflammatory Action of Calorie Restriction Underlies the Retardation of Aging and Age-Related Diseases
Dae Hyun Kim,Eun Kyeong Lee,Min Hi Park,Byoung Chul Kim,Ki Wung Chung,Byung Pal Yu,Hae Young Chung +6 more
TL;DR: The evidence that CR suppresses molecular inflammation through the proper maintenance of redox status, NF-κB signaling, inflammasome activation, ER stress, and insulin sensitivity is summarized, which in turn lead to the intervention of aging processes and age-related diseases.
Journal ArticleDOI
The Immune System as a Therapeutic Target for Alzheimer’s Disease
TL;DR: There is an intricate connection between the immune and central nervous systems, which can be imbalanced and thereby mediate neuroinflammation and AD and how it can be altered with AD is examined.
Journal ArticleDOI
The NLRP3 inflammasome as a target for sensorineural hearing loss.
TL;DR: In this paper , the evidence for the NLRP3 inflammasome and associated cytokines as potential therapeutic targets for sensorineural hearing loss in conditions ranging from auto-inflammatory disease to tumour-induced hearing loss.
Journal ArticleDOI
Microglia: Rheostats of space radiation effects in the CNS microenvironment.
TL;DR: In this article , the authors highlight aspects of microglial biology and how repeated insults that occur with age, neurodegenerative disease and possibly radiation exposure may heighten microglia responses and contribute to their dysfunction, creating a situation where their normal reparative mechanisms are no longer sufficient to maintain brain health.
Journal ArticleDOI
Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications
Priyanka Banerjee,Elizabeth A. Olmsted-Davis,Anita Deswal,Minh-Thuy Nguyen,Efstratios Koutroumpakis,Nick Palaskas,Steven H. Lin,Sivareddy Kotla,Cielito C. Reyes-Gibby,Sai Ching J. Yeung,Syed Wamique Yusuf,Momoko Yoshimoto,Michihiro Kobayashi,Bing Yu,Keri Schadler,A. Herrmann,John P. Cooke,Abhishek Jain,Eduardo N. Chini,Nhat Tu Le,Jun Ichi Abe +20 more
TL;DR: The role of NAD+ depletion in instigating SASP and its downstream signaling and regulatory mechanisms that lead to the premature onset of atherosclerotic cardiovascular diseases in cancer survivors are discussed.
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