Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm,Ryan W. Grant,Laura R. McCabe,Diana C. Albarado,Kim Y. Nguyen,Anthony Ravussin,Paul J. Pistell,Susan Newman,Renee T. Carter,Amanda Laque,Heike Münzberg,Clifford J. Rosen,Donald K. Ingram,J. Michael Salbaum,Vishwa Deep Dixit,Vishwa Deep Dixit +15 more
TLDR
Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.About:
This article is published in Cell Metabolism.The article was published on 2013-10-01 and is currently open access. It has received 469 citations till now. The article focuses on the topics: Inflammasome & Systemic inflammation.read more
Citations
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Journal ArticleDOI
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Christina Camell,Patrick Günther,Aileen Lee,Emily L. Goldberg,Olga Spadaro,Yun-Hee Youm,Andrzej Bartke,Gene Hubbard,Yuji Ikeno,Nancy H. Ruddle,Joachim L. Schultze,Joachim L. Schultze,Vishwa Deep Dixit +12 more
TL;DR: The data reveal that inhibiting Nlrp3-dependent B cell accumulation can be targeted to reverse metabolic impairment in aging AT and reveal that whole-body B cell depletion restores proper lipolysis and core body temperature maintenance during cold stress.
Journal ArticleDOI
Inflammasome-Independent Role of NLRP3 Mediates Mitochondrial Regulation in Renal Injury.
Su-Mi Kim,Yang Gyun Kim,Dong-Jin Kim,Seon Hwa Park,Kyung-Hwan Jeong,Yu Ho Lee,Sung Jig Lim,Sang-Ho Lee,Ju-Young Moon +8 more
TL;DR: It is suggested that inflammasome-independent NLRP3 could be a therapeutic target of AKI to prevent the progression of chronic kidney disease and play important role in mitochondrial ROS production and injury by binding to MAVS after hypoxic injury.
Journal ArticleDOI
Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly.
TL;DR: Age-associated changes in DC function in humans mean the secretion of innate protective cytokines such as type I and III interferons is decreased, and the function of DCs in airway remodeling and inflammation in aged is also compromised.
Journal ArticleDOI
Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing
TL;DR: The complete loss of the PYHIN gene family is confirmed, with only a truncated AIM2 remaining in one species (Pteronotus parnellii), which may indicate an important adaptation that is flight-induced and related, at least in part, to pathogen-host co-existence.
Journal ArticleDOI
NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice
Fabiola Marín-Aguilar,Ana Victoria Lechuga-Vieco,Elísabet Alcocer-Gómez,Beatriz Castejón-Vega,Javier Lucas,Carlos Garrido,Alejandro Peralta‐Garcia,Antonio J. Pérez-Pulido,Alfonso Varela-López,José L. Quiles,Bernhard Ryffel,Bernhard Ryffel,Ignacio Flores,Pedro Bullón,Jesús Ruiz-Cabello,Mario D. Cordero +15 more
TL;DR: It is suggested that suppression of NLRP3 prevented many age‐associated changes in the heart, preserved cardiac function of aged mice and increased lifespan.
References
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TL;DR: The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data and provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-power gene expression and genomic hybridization experiments.
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TL;DR: The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
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Immunological and Inflammatory Functions of the Interleukin-1 Family
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