Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm,Ryan W. Grant,Laura R. McCabe,Diana C. Albarado,Kim Y. Nguyen,Anthony Ravussin,Paul J. Pistell,Susan Newman,Renee T. Carter,Amanda Laque,Heike Münzberg,Clifford J. Rosen,Donald K. Ingram,J. Michael Salbaum,Vishwa Deep Dixit,Vishwa Deep Dixit +15 more
TLDR
Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.About:
This article is published in Cell Metabolism.The article was published on 2013-10-01 and is currently open access. It has received 469 citations till now. The article focuses on the topics: Inflammasome & Systemic inflammation.read more
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Astrocyte to microglia cross-talk in acute and chronic neuroinflammation is shaped by SFRP1
Javier Rueda-Carrasco,María Inés Mateo,Aldo Borroto,María Jesús Martín-Bermejo,Markus P. Kummer,Stephanie Schwartz,José P. López-Atalaya,Balbino Alarcón,Michael T. Heneka,Pilar Esteve,Paola Bovolenta +10 more
TL;DR: It is proposed that SFRP1 acts as a critical astrocyte to microglia amplifier of neuroinflammation, representing a potential valuable therapeutic target for counteracting the harmful effect of chronic inflammation present in several neurodegenerative diseases.
Journal ArticleDOI
Gut microbiome sheds light on the development and treatment of abdominal aortic aneurysm
TL;DR: In this article , a review summarizes the direct and indirect effects of the gut microbiome on the pathogenesis of abdominal aortic aneurysm and highlights the Gut microbiome-mediated inflammatory responses and discoveries of relevant therapeutic targets that may help manage the development and rupture of AAA.
Book ChapterDOI
Biomedical Research in Aging
TL;DR: Current knowledge regarding the significance of hallmarks such as: decay of stem cell function, acquisition of genomic instability, DNA damage, telomere attrition, deregulated nutrient sensing, chronic inflammation and cellular senescence are discussed.
Journal ArticleDOI
Inflammatory stimuli alter bone marrow composition and compromise bone health in the malnourished host
E. Yaneth Osorio,Zbigniew Gugala,Grace T. Patterson,Génesis Palacios,Erika G. Cordova,Ashanti Concepción Uscanga-Palomeque,Bruno L. Travi,Peter C. Melby +7 more
TL;DR: It is demonstrated that the negative effect of inflammatory challenge on bone marrow is amplified in the malnourished host and increasing dietary intake of omega-3 fatty acids may be a means to reduce inflammation and improve bone health in malnouredished children.
Journal ArticleDOI
Regular physical activity reduces the effects of inflammaging in diabetic and hypertensive men.
Israel S. Ribeiro,Ítalo Sousa Pereira,Maria Poliana Leite Galantini,Denisar Palmito dos Santos,Mauro F. Teles,Igor Pereira Ribeiro Muniz,Gilvanéia S. Santos,Robson Amaro Augusto da Silva +7 more
TL;DR: In this paper, the influence of physical activity in inflammatory, biochemical and endocrine parameters of middle-aged and elderly men with Systemic Arterial Hypertension (SAH) and Type 2 Diabetes Mellitus (T2DM) was assessed.
References
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TL;DR: The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data and provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-power gene expression and genomic hybridization experiments.
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.
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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
Claudio Franceschi,Massimiliano Bonafè,Silvana Valensin,Fabiola Olivieri,Maria De Luca,Enzo Ottaviani,Giovanna De Benedictis +6 more
TL;DR: The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
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Immunological and Inflammatory Functions of the Interleukin-1 Family
TL;DR: The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response.
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