Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm,Ryan W. Grant,Laura R. McCabe,Diana C. Albarado,Kim Y. Nguyen,Anthony Ravussin,Paul J. Pistell,Susan Newman,Renee T. Carter,Amanda Laque,Heike Münzberg,Clifford J. Rosen,Donald K. Ingram,J. Michael Salbaum,Vishwa Deep Dixit,Vishwa Deep Dixit +15 more
TLDR
Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.About:
This article is published in Cell Metabolism.The article was published on 2013-10-01 and is currently open access. It has received 469 citations till now. The article focuses on the topics: Inflammasome & Systemic inflammation.read more
Citations
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The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging.
Seungjin Ryu,Sviatoslav Sidorov,Eric Ravussin,Maxim N. Artyomov,Akiko Iwasaki,Andrew Wang,Vishwa Deep Dixit +6 more
TL;DR: In this paper , a CR-mimetic adipokine, SPARC, was found to be an immunometabolic checkpoint of inflammation and interferon response that may be targeted to delay agerelated metabolic and functional decline.
Journal ArticleDOI
Treatment options for anemia in the elderly.
TL;DR: A number of innovative anti-anemic drugs, like hepcidin modulators, Hypoxia Inducible Factor (HIF) stabilizers, and activin type II receptor agonists are entering the clinical arena and may substantially improve the therapeutic armamentarium to AE in the near future.
Journal ArticleDOI
NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats.
Lin Chen,Ping‑Lin He,Jin Yang,Ya-Fei Yang,Kai Wang,Bastian Amend,Arnulf Stenzl,Ya‑Mei Zhang,Zi‑Li Wang,Sha‑Sha Xing,Xu Luo +10 more
TL;DR: In the histological examination, the bladders of the old group displayed increased collagen deposition, urothelial thinning and detrusor shrinkage compared with the young group, which led to chronic bladder fibrosis with increased NLRP3.
Journal ArticleDOI
Thioredoxin interacting protein regulates age-associated neuroinflammation.
Saifudeen Ismael,Sanaz Nasoohi,Sanaz Nasoohi,Lexiao Li,Khurram S. Aslam,Mohammad Moshahid Khan,Azza B. El-Remessy,Michael P. McDonald,Francesca-Fang Liao,Tauheed Ishrat +9 more
TL;DR: In this paper, the authors found that TXNIP was significantly upregulated in aged animals, paralleled by the NLRP3-inflammasome over-activity leading to enhanced caspase-1 cleavage and IL-1β maturation, in both sexes.
Journal ArticleDOI
Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging
Andrea Irazoki,Marta Martinez-Vicente,Pilar Aparicio,Cecilia Aris,Esmaeil Alibakhshi,Maria Rubio-Valera,Juan Heber Castellanos,Luis Lores,Manuel Palacín,Anna Gumà,Antonio Zorzano,David Sebastian +11 more
TL;DR: It is demonstrated that BCL2 interacting protein 3 (BNIP3) plays a key role in the control of mitochondrial and lysosomal homeostasis, and mitigates muscle inflammation and atrophy during aging, and a new adaptive mechanism involving the mitophagy protein BNIP3 is proposed.
References
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TL;DR: The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
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