Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm,Ryan W. Grant,Laura R. McCabe,Diana C. Albarado,Kim Y. Nguyen,Anthony Ravussin,Paul J. Pistell,Susan Newman,Renee T. Carter,Amanda Laque,Heike Münzberg,Clifford J. Rosen,Donald K. Ingram,J. Michael Salbaum,Vishwa Deep Dixit,Vishwa Deep Dixit +15 more
TLDR
Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.About:
This article is published in Cell Metabolism.The article was published on 2013-10-01 and is currently open access. It has received 469 citations till now. The article focuses on the topics: Inflammasome & Systemic inflammation.read more
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Dissertation
Rôle des calpaïnes dans le vieillissement et la réponse anti-tumorale
TL;DR: In this paper, it was shown that the calpaines 1 and 2 sont impliquees dans le developpement de la reponse inflammatoire via l’activation par proteolyse partielle de plusieurs substrats (activation de NF-κB par le clivage de IκBα, remodelage du cytosquelette des cellules inflammatoires, clivages de la proteine chaperonne HSP 90, etc.).
Journal ArticleDOI
Gaucher disease-associated alterations in mesenchymal stem cells reduce osteogenesis and favour adipogenesis processes with concomitant increased osteoclastogenesis.
Andrea Crivaro,Constanza María Bondar,Juan Marcos Mucci,Maximiliano Ormazabal,Ricardo A. Feldman,María Victoria Delpino,Paula Rozenfeld +6 more
TL;DR: Evaluating the potential of MSCs from GD patients to differentiate towards the osteoblast (GD Ob) and adipocyte (GD Ad) lineages and their role in osteoclastogenesis showed that GD M SCs exhibited deficient GD Ob differentiation and increased adipogenesis, likely to contribute to skeletal imbalance observed in GD patients.
Dissertation
Age-associated inflammation impairs myeloid development and monocyte and macrophage function
TL;DR: I have learned by reading books, papers, and papers and relentlessly recruiting study participants to help me improve my own understanding of human trafficking.
Book ChapterDOI
Mitochondria-Associated Inflammasome Activation and Its Impact on Aging and Age-Related Diseases
Book ChapterDOI
Brain Inflammation and Endoplasmic Reticulum Stress
Isin Cakir,Eduardo A. Nillni +1 more
TL;DR: Low-grade chronic inflammation has been demonstrated in a variety of metabolic tissues, such as the white adipose, liver, and pancreas, and appears to play a causative role in metabolic dysregulations including insulin resistance during obesity.
References
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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
TL;DR: The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data and provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-power gene expression and genomic hybridization experiments.
Journal ArticleDOI
Gout-associated uric acid crystals activate the NALP3 inflammasome
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
Journal ArticleDOI
Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.
Alvis Brazma,Pascal Hingamp,John Quackenbush,Gavin Sherlock,Paul T. Spellman,Chris Stoeckert,John Aach,Wilhelm Ansorge,Catherine A. Ball,Helen C. Causton,Terry Gaasterland,Patrick Glenisson,Frank C. P. Holstege,Irene F. Kim,Victor Markowitz,John C. Matese,Helen Parkinson,Alan J. Robinson,Ugis Sarkans,Steffen Schulze-Kremer,Jason E. Stewart,Ronald C. Taylor,Jaak Vilo,Martin Vingron +23 more
TL;DR: The ultimate goal of this work is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools.
Journal ArticleDOI
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
Claudio Franceschi,Massimiliano Bonafè,Silvana Valensin,Fabiola Olivieri,Maria De Luca,Enzo Ottaviani,Giovanna De Benedictis +6 more
TL;DR: The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
Journal ArticleDOI
Immunological and Inflammatory Functions of the Interleukin-1 Family
TL;DR: The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response.
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Peter Duewell,Hajime Kono,Katey J. Rayner,Katey J. Rayner,Cherilyn M. Sirois,Gregory I. Vladimer,Franz Bauernfeind,George S. Abela,Luigi Franchi,Guillermo Gabriel Nuñez,Max Schnurr,Terje Espevik,Egil Lien,Katherine A. Fitzgerald,Kenneth L. Rock,Kathryn J. Moore,Kathryn J. Moore,Samuel D. Wright,Veit Hornung,Eicke Latz,Eicke Latz +20 more