Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm,Ryan W. Grant,Laura R. McCabe,Diana C. Albarado,Kim Y. Nguyen,Anthony Ravussin,Paul J. Pistell,Susan Newman,Renee T. Carter,Amanda Laque,Heike Münzberg,Clifford J. Rosen,Donald K. Ingram,J. Michael Salbaum,Vishwa Deep Dixit,Vishwa Deep Dixit +15 more
TLDR
Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.About:
This article is published in Cell Metabolism.The article was published on 2013-10-01 and is currently open access. It has received 469 citations till now. The article focuses on the topics: Inflammasome & Systemic inflammation.read more
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Dissertation
Analysis of Inflammatory Phenotype in Human Endothelial Cell Senescence
TL;DR: The author states that the aim of this book was to provide a history of English-language computer programming in the 21st Century and specifically to clarify the role that computer programming played in the development of computer programming languages.
Journal ArticleDOI
Vitamin D as a Shield against Aging
TL;DR: In this article , the role of vitamin D in geroprotection is discussed, based on its ability to shape cellular/intracellular processes and drive the immune response toward immune protection against infections and age-related diseases.
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Therapeutic Antiaging Strategies
TL;DR: In this paper , the most important antiaging strategies that researchers have proposed, including preventive measures, systemic therapeutic agents, and invasive procedures, that will promote healthy aging and increase human life expectancy with decreased side effects.
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Age‐associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis
Jianrui Song,Diana M. Farris,Paola Ariza,Smriti Moorjani,Mita Varghese,Muriel G. Blin,Judy Fuh-Meei Chen,Daniel J. Tyrrell,Jinghui Zhang,Kanakadurga Singer,Morgan Salmon,Daniel R Goldstein +11 more
TL;DR: In this article , the authors examined whether aging exerts a direct pro-atherogenic effect on adipose tissue in mice and found that aging enhances atherosclerosis via increased inflammation of visceral fat.
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In silico clinical trials for anti-aging therapies.
Javier A. Menendez,Elisabet Cuyàs,Núria Folguera-Blasco,Sara Verdura,Begoña Martin-Castillo,Jorge Joven,Tomás Alarcón +6 more
TL;DR: It is proposed that stochastic biomathematical modeling and computational simulation platforms should be developed as in silico strategies to accelerate the performance of clinical trials targeting human aging, and to provide personalized approaches and robust biomarkers of healthy aging at the individual-to-population levels.
References
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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TL;DR: The ultimate goal of this work is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools.
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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
Claudio Franceschi,Massimiliano Bonafè,Silvana Valensin,Fabiola Olivieri,Maria De Luca,Enzo Ottaviani,Giovanna De Benedictis +6 more
TL;DR: The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
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Immunological and Inflammatory Functions of the Interleukin-1 Family
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