Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm,Ryan W. Grant,Laura R. McCabe,Diana C. Albarado,Kim Y. Nguyen,Anthony Ravussin,Paul J. Pistell,Susan Newman,Renee T. Carter,Amanda Laque,Heike Münzberg,Clifford J. Rosen,Donald K. Ingram,J. Michael Salbaum,Vishwa Deep Dixit,Vishwa Deep Dixit +15 more
TLDR
Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.About:
This article is published in Cell Metabolism.The article was published on 2013-10-01 and is currently open access. It has received 469 citations till now. The article focuses on the topics: Inflammasome & Systemic inflammation.read more
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Inflammaging: mechanisms and role in the cardiac and vasculature
Amir Ajoolabady,Domenico Praticò,Manlio Vinciguerra,Gregory Y.H. Lip,Claudio Franceschi,Jun Ren +5 more
TL;DR: In this article , the authors survey molecular and pathological mechanisms of inflammaging in vascular and cardiac aging to identify potential targets, natural therapeutic compounds, and other strategies to suppress inflammaging, as well as associated diseases such as atherosclerosis and hypertension.
Journal ArticleDOI
The NLRP3 Inflammasome in Age-Related Cerebral Small Vessel Disease Manifestations: Untying the Innate Immune Response Connection
Che Mohd Nasril Che Mohd Nassir,Thenmoly Damodaran,Nurul Iman Ismail,Sabar Bin Md Hashim,Usman Jaffer,Hafizah A. Hamid,Muhammad Zulfadli Mehat,Anwar Norazit,Muzaimi Mustapha +8 more
TL;DR: In this paper , the evidence on nucleotide-binding and oligomerization (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome activation for its putative roles in the elusive pathomechanism of aging-related cerebral small vessel disease (CSVD).
Posted ContentDOI
Necroptosis contributes to chronic inflammation and fibrosis in aging liver
Sabira Mohammed,Nidheesh Thadathil,Ramasamy Selvarani,Evan H Nicklas,Dawei Wang,Benjamin F. Miller,Benjamin F. Miller,Arlan Richardson,Sathyaseelan S. Deepa +8 more
TL;DR: Vardef et al. as discussed by the authors showed that liver aging is associated with increased necroptosis and contributes to chronic inflammation in the liver, which in turn appears to contribute to liver fibrosis and possibly chronic liver disease.
References
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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
TL;DR: The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data and provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-power gene expression and genomic hybridization experiments.
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.
Alvis Brazma,Pascal Hingamp,John Quackenbush,Gavin Sherlock,Paul T. Spellman,Chris Stoeckert,John Aach,Wilhelm Ansorge,Catherine A. Ball,Helen C. Causton,Terry Gaasterland,Patrick Glenisson,Frank C. P. Holstege,Irene F. Kim,Victor Markowitz,John C. Matese,Helen Parkinson,Alan J. Robinson,Ugis Sarkans,Steffen Schulze-Kremer,Jason E. Stewart,Ronald C. Taylor,Jaak Vilo,Martin Vingron +23 more
TL;DR: The ultimate goal of this work is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools.
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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
Claudio Franceschi,Massimiliano Bonafè,Silvana Valensin,Fabiola Olivieri,Maria De Luca,Enzo Ottaviani,Giovanna De Benedictis +6 more
TL;DR: The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
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Immunological and Inflammatory Functions of the Interleukin-1 Family
TL;DR: The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response.
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