Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm,Ryan W. Grant,Laura R. McCabe,Diana C. Albarado,Kim Y. Nguyen,Anthony Ravussin,Paul J. Pistell,Susan Newman,Renee T. Carter,Amanda Laque,Heike Münzberg,Clifford J. Rosen,Donald K. Ingram,J. Michael Salbaum,Vishwa Deep Dixit,Vishwa Deep Dixit +15 more
TLDR
Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.About:
This article is published in Cell Metabolism.The article was published on 2013-10-01 and is currently open access. It has received 469 citations till now. The article focuses on the topics: Inflammasome & Systemic inflammation.read more
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Specks of insight into Alzheimer's disease.
TL;DR: It emerges that specks of ASC promote a hallmark of Alzheimer’s disease in the brains of mice — aggregation and deposition of amyloid-β protein.
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SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammation
Javier Rueda-Carrasco,María Jesús Martín-Bermejo,Guadalupe Pereyra,María Inés Mateo,Aldo Borroto,Frederic Brosseron,Frederic Brosseron,Markus P. Kummer,Markus P. Kummer,Stephanie Schwartz,Stephanie Schwartz,José P. López-Atalaya,Balbino Alarcón,Pilar Esteve,Michael T. Heneka,Michael T. Heneka,Paola Bovolenta +16 more
TL;DR: In this article, the secreted frizzled-related protein 1 (SFRP1) is shown to be an astrocyte-to-microglia amplifier of neuroinflammation, representing a potential therapeutic target for counteracting the harmful effect of chronic inflammation in several neurodegenerative diseases.
Journal ArticleDOI
Astrocyte immunosenescence and deficits in interleukin 10 signaling in the aged brain disrupt the regulation of microglia following innate immune activation
TL;DR: Astrocytes had an immunosenescent profile with age and, in response to peripheral LPS, had IL‐10R signaling deficits and a lack of cholesterol biosynthesis, both leading to the inability to resolve microglial activation.
Journal ArticleDOI
NOD-like receptor pyrin domain-containing-3 (NLRP3) regulates inflammation-induced pro-labor mediators in human myometrial cells.
TL;DR: The effect of term labor on the expression of NLRP3 in human myometrium and the effect ofNLRP3 silencing on pro‐labor mediators in myometrial cells are determined.
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DAMPs and influenza virus infection in ageing.
TL;DR: The detriment in the immune system during ageing and the links between influenza virus infection and ageing will be discussed and the role of DAMPs such as HMGB1 and S100/Annexin in ageing, and the enhanced morbidity and mortality to severe influenza infection in ageing will been highlighted.
References
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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
TL;DR: The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data and provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-power gene expression and genomic hybridization experiments.
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Gout-associated uric acid crystals activate the NALP3 inflammasome
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
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Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.
Alvis Brazma,Pascal Hingamp,John Quackenbush,Gavin Sherlock,Paul T. Spellman,Chris Stoeckert,John Aach,Wilhelm Ansorge,Catherine A. Ball,Helen C. Causton,Terry Gaasterland,Patrick Glenisson,Frank C. P. Holstege,Irene F. Kim,Victor Markowitz,John C. Matese,Helen Parkinson,Alan J. Robinson,Ugis Sarkans,Steffen Schulze-Kremer,Jason E. Stewart,Ronald C. Taylor,Jaak Vilo,Martin Vingron +23 more
TL;DR: The ultimate goal of this work is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools.
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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
Claudio Franceschi,Massimiliano Bonafè,Silvana Valensin,Fabiola Olivieri,Maria De Luca,Enzo Ottaviani,Giovanna De Benedictis +6 more
TL;DR: The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
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Immunological and Inflammatory Functions of the Interleukin-1 Family
TL;DR: The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response.
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