Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm,Ryan W. Grant,Laura R. McCabe,Diana C. Albarado,Kim Y. Nguyen,Anthony Ravussin,Paul J. Pistell,Susan Newman,Renee T. Carter,Amanda Laque,Heike Münzberg,Clifford J. Rosen,Donald K. Ingram,J. Michael Salbaum,Vishwa Deep Dixit,Vishwa Deep Dixit +15 more
TLDR
Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.About:
This article is published in Cell Metabolism.The article was published on 2013-10-01 and is currently open access. It has received 469 citations till now. The article focuses on the topics: Inflammasome & Systemic inflammation.read more
Citations
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Journal ArticleDOI
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
TL;DR: The session on inflammation of the Advances in Gerosciences meeting held at the National Institutes of Health/National Institute on Aging in Bethesda on October 30 and 31, 2013 was aimed at defining these important unanswered questions about inflammaging.
Journal ArticleDOI
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Rebecca C. Coll,Avril A. B. Robertson,Jae Jin Chae,Sarah C. Higgins,Raúl Muñoz-Planillo,Marco Inserra,Irina Vetter,Lara S. Dungan,Brian G. Monks,Andrea Stutz,Daniel E. Croker,Mark S. Butler,Moritz Haneklaus,Caroline E. Sutton,Gabriel Núñez,Eicke Latz,Daniel L. Kastner,Kingston H. G. Mills,Seth L. Masters,Kate Schroder,Mark E. Cooper,Luke A. J. O'Neill +21 more
TL;DR: MCC950 treatment rescued neonatal lethality in a mouse model of CAPS and was active in ex vivo samples from individuals with Muckle–Wells syndrome, and is a potential therapeutic for NLRP3-associated syndromes, and a tool for further study of theNLRP3 inflammasome in human health and disease.
Journal ArticleDOI
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Luigi Ferrucci,Elisa Fabbri +1 more
TL;DR: Whether therapies to modulate inflammageing can reduce the age-related decline in health is discussed, and the hypothesis that inflammation affects CVD, multimorbidity, and frailty is supported by mechanistic studies but requires confirmation in humans.
Journal ArticleDOI
Ageing as a risk factor for neurodegenerative disease.
Yujun Hou,Xiuli Dan,Mansi Babbar,Yong Wei,Steen G. Hasselbalch,Deborah L. Croteau,Vilhelm A. Bohr,Vilhelm A. Bohr +7 more
TL;DR: Hallmarks of ageing — genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication — correlate with susceptibility to neurodegenerative disease.
Journal ArticleDOI
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
Yun-Hee Youm,Kim Y. Nguyen,Ryan W. Grant,Emily L. Goldberg,Monica Bodogai,Dongin Kim,Dominic P. D’Agostino,Noah J. Planavsky,Christopher R. Lupfer,Thirumala D. Kanneganti,Seokwon Kang,Tamas L. Horvath,Tarek M. Fahmy,Peter A. Crawford,Arya Biragyn,Emad S. Alnemri,Vishwa Deep Dixit +16 more
TL;DR: In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1β secretion in mouse models of NLRP3-mediated diseases such as Muckle–Wells syndrome, familial cold autoinflammatory syndrome and urate crystal–induced peritonitis and the findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of theNLRP3 inflammasome.
References
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Carey N. Lumeng,Jianhua Liu,Lynn M. Geletka,Colin Delaney,Jennifer B. DelProposto,Anjali Desai,Kelsie E. Oatmen,Gabriel Martinez-Santibanez,Annabelle Julius,Sanjay K. Garg,Raymond Yung,Raymond Yung +11 more
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