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Open AccessJournal ArticleDOI

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

TLDR
Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.
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Ipriflavone suppresses NLRP3 inflammasome activation in host response to biomaterials and promotes early bone healing.

TL;DR: An anti-inflammatory role of ipriflavone is revealed in NLRP3 inflammasome activation through improving mitochondrial function and provides a new strategy for the development of immune-regulated biomaterials and treatment options for NLRP2-related diseases.
Journal ArticleDOI

Udział zapalenia starczego w procesie onkogenezy

TL;DR: Wzrost zachorowalnoŚci i śmiertelności na nowotwory, zwłaszcza złośliwe, jest wprost proporcjonalny do procesu starzenia się organizmu i tak 80%nowotworów u ludzi pojawia si’ powyżej 55.
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Age-related blunting of the phagocyte arsenal and its art of killing

TL;DR: A detailed mechanistic approach of the phagocytosis process is reviewed, in the context of the age-dependent alterations of this phenomenon, to help understand the decline in essential functions of phagocytes with age.
Posted ContentDOI

Long-read sequencing reveals rapid evolution of immunity- and cancer-related genes in bats

TL;DR: In this paper, the authors sequenced the genomes of the Jamaican fruit bat (Artibeus jamaicensis) and the Mesoamerican mustached bat (Pteronotus mesoamericaus) and compared them to a diverse collection of 13 additional bat species together with other mammals.
Journal ArticleDOI

Actions of the NLRP3 and NLRC4 inflammasomes overlap in bone resorption.

TL;DR: In this article, the interaction between the NLRP3 and NLRC4 inflammasomes in bone homeostasis and disease was studied, and it was shown that loss of either inflammeme attenuated osteoclast differentiation in vitro.
References
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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

TL;DR: The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data and provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-power gene expression and genomic hybridization experiments.
Journal ArticleDOI

Gout-associated uric acid crystals activate the NALP3 inflammasome

TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
Journal ArticleDOI

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

TL;DR: The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
Journal ArticleDOI

Immunological and Inflammatory Functions of the Interleukin-1 Family

TL;DR: The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response.
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