Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm,Ryan W. Grant,Laura R. McCabe,Diana C. Albarado,Kim Y. Nguyen,Anthony Ravussin,Paul J. Pistell,Susan Newman,Renee T. Carter,Amanda Laque,Heike Münzberg,Clifford J. Rosen,Donald K. Ingram,J. Michael Salbaum,Vishwa Deep Dixit,Vishwa Deep Dixit +15 more
TLDR
Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.About:
This article is published in Cell Metabolism.The article was published on 2013-10-01 and is currently open access. It has received 469 citations till now. The article focuses on the topics: Inflammasome & Systemic inflammation.read more
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Integrating the "Immunome" in the Stratification of Myelodysplastic Syndromes and Future Clinical Trial Design.
Susann Winter,Susann Winter,Susann Winter,Saeed Shoaie,Saeed Shoaie,Shahram Kordasti,Shahram Kordasti,Uwe Platzbecker +7 more
TL;DR: The existing knowledge is reviewed and how state-of-the-art immune monitoring strategies could potentially permit novel patient substratification, thereby empowering practical predictions of response to treatment in MDS is discussed.
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Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain.
TL;DR: A major cytokine-regulatory loop between activated microglia and astrocytes is impaired in the aged brain, resulting in a failure to induce IL-10R1 and transforming growth factor β and resolve microglial activation.
Journal ArticleDOI
Damage-associated molecular patterns and their pathological relevance in diabetes mellitus.
TL;DR: Current research on the function(s) of inflammasomes and DAMPs is reviewed and their pathological relevance and therapeutic implications in diabetes are discussed.
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NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction.
Luis E Pavillard,Diego Cañadas-Lozano,Elísabet Alcocer-Gómez,Fabiola Marín-Aguilar,Sheila Pereira,Avril A. B. Robertson,Jordi Muntané,Jordi Muntané,Bernhard Ryffel,Mark E. Cooper,José L. Quiles,Pedro Bullón,Jesús Ruiz-Cabello,Mario D. Cordero +13 more
TL;DR: Cardiac damage induced by high sugar diet, high fat diet (HFD) or high sugar/fat diet (HSFD) over 15 weeks is shown and genetic ablation of NLRP3 protected against this damage by autophagy induction and apoptotic control.
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Innate immune perturbations, accumulating DAMPs and inflammasome dysregulation: A ticking time bomb in ageing.
TL;DR: The evidence that dysregulated inflammasome activation, via altered innate immune cell functions and elevated levels of DAMPs, contributes to the establishment of chronic, low-grade inflammation and the development of age-related pathological processes is reviewed.
References
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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
TL;DR: The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data and provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-power gene expression and genomic hybridization experiments.
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.
Alvis Brazma,Pascal Hingamp,John Quackenbush,Gavin Sherlock,Paul T. Spellman,Chris Stoeckert,John Aach,Wilhelm Ansorge,Catherine A. Ball,Helen C. Causton,Terry Gaasterland,Patrick Glenisson,Frank C. P. Holstege,Irene F. Kim,Victor Markowitz,John C. Matese,Helen Parkinson,Alan J. Robinson,Ugis Sarkans,Steffen Schulze-Kremer,Jason E. Stewart,Ronald C. Taylor,Jaak Vilo,Martin Vingron +23 more
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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
Claudio Franceschi,Massimiliano Bonafè,Silvana Valensin,Fabiola Olivieri,Maria De Luca,Enzo Ottaviani,Giovanna De Benedictis +6 more
TL;DR: The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
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Immunological and Inflammatory Functions of the Interleukin-1 Family
TL;DR: The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response.
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