Journal ArticleDOI
Cell-penetrating peptides: strategies for anticancer treatment
Drazen Raucher,Jung Su Ryu +1 more
TLDR
This review focuses on recent advances in the use of CPPs to deliver anticancer therapeutics and imaging reagents to cancer cells, along with CPP contributions to novel tumor-targeting techniques.About:
This article is published in Trends in Molecular Medicine.The article was published on 2015-09-01. It has received 190 citations till now. The article focuses on the topics: Cell-penetrating peptide & Drug delivery.read more
Citations
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Journal ArticleDOI
Cell-Penetrating Peptides: From Basic Research to Clinics
TL;DR: In this article, cell-penetrating peptides (CPPs) have been used to increase medicament concentrations in areas that are difficult to access, which can transport into the cell a wide variety of biologically active conjugates.
Journal ArticleDOI
CPPsite 2.0: a repository of experimentally validated cell-penetrating peptides
Piyush Agrawal,Sherry Bhalla,Salman Sadullah Usmani,Sandeep Singh,Kumardeep Chaudhary,Gajendra P. S. Raghava,Ankur Gautam +6 more
TL;DR: In order to understand the structure-function relationship of these peptides, the predicted tertiary structure of CPPs, possessing both modified and natural residues, using state-of-the-art techniques are predicted.
Journal ArticleDOI
Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents.
TL;DR: This review describes the several types of CPPs, the chemical modifications to improve their cellular uptake, the different mechanisms to cross cell membranes and their biological properties upon conjugation with specific molecules.
Journal ArticleDOI
Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses
Jesse M. Jaynes,Rushikesh Sable,Michael Ronzetti,Wendy Bautista,Zachary Knotts,Abisola Abisoye-Ogunniyan,Dandan Li,Raul Calvo,Myagmarjav Dashnyam,Anju Singh,Theresa Guerin,Jason White,Sarangan Ravichandran,Parimal Kumar,Keyur Talsania,Vicky Chen,Anghesom Ghebremedhin,Balasubramanyam Karanam,Ahmad Bin Salam,Ruksana Amin,Taivan Odzorig,Taylor Aiken,Victoria Nguyen,Yansong Bian,Jelani C. Zarif,Amber E. de Groot,Monika Mehta,Lixin Fan,Xin Hu,Anton Simeonov,Nathan Pate,Mones Abu-Asab,Marc Ferrer,Noel Southall,Chan Young Ock,Yongmei Zhao,Henry Lopez,Serguei Kozlov,Natalia de Val,Natalia de Val,Clayton Yates,Bolormaa Baljinnyam,Juan J. Marugan,Udo Rudloff +43 more
TL;DR: RP-182 as mentioned in this paper is a synthetic 10-mer amphipathic analog of host defense peptides that selectively induces a conformational switch of the mannose receptor CD206 expressed on TAMs displaying an M2-like phenotype.
Journal ArticleDOI
Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids
Rey W. Martin,Benjamin J. Des Soye,Yong-Chan Kwon,Jennifer E. Kay,Roderick G. Davis,Paul M. Thomas,Natalia I. Majewska,Cindy X. Chen,Ryan D. Marcum,Mary Grace Weiss,Ashleigh E. Stoddart,Miriam Amiram,Arnaz K. Ranji Charna,Jaymin R. Patel,Farren J. Isaacs,Neil L. Kelleher,Seok Hoon Hong,Michael C. Jewett +17 more
TL;DR: A cell-free synthesis method that enables incorporating non-standard amino acids in the product, and the ability to introduce 40 identical p-acetyl-l-phenylalanine residues site specifically into an elastin-like polypeptide, is developed.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Liposomal drug delivery systems: from concept to clinical applications.
TL;DR: Lipidic nanoparticles are the first nanomedicine delivery system to make the transition from concept to clinical application, and they are now an established technology platform with considerable clinical acceptance.
Journal ArticleDOI
Cellular uptake of the tat protein from human immunodeficiency virus
Alan D. Frankel,Carl O. Pabo +1 more
TL;DR: Experiments using radioactive protein show that tat becomes localized to the nucleus after uptake and suggest that chloroquine protects tat from proteolytic degradation, raising the possibility that, under some conditions, tat might act as a viral growth factor to stimulate viral replication in latently infected cells or alter expression of cellular genes.
Journal Article
Acid pH in Tumors and Its Potential for Therapeutic Exploitation
Ian F. Tannock,Daniela Rotin +1 more
TL;DR: Measurement of pH in tissue has shown that the microenvironment in tumors is generally more acidic than in normal tissues, and acid conditions in tumors might allow the development of new and relatively specific types of therapy which are directed against mechanisms which regulate pHi under acid conditions.
PatentDOI
Cell penetrating peptides
TL;DR: In this article, the present invention discloses cell penetrating peptides and conjugates of a cell-penetrating peptide and a cargo molecule, as well as their conjugations.