Journal ArticleDOI
Chemistry and application of 4-oxo-4H-1-benzopyran-3-carboxaldehyde
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TLDR
The chemistry and application of the title aldehyde and some simple derivatives thereof are reviewed in this paper, where the authors propose a simple derivative of the aldehydes, which they call simple aldeheeds.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2008-11-01. It has received 42 citations till now. The article focuses on the topics: Benzopyran.read more
Citations
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One-pot synthesis of chromenylfurandicarboxylates and cyclopenta[b]chromenedicarboxylates involving zwitterionic intermediates. A DFT investigation on the regioselectivity of the reaction.
TL;DR: The reactants, intermediate zwitterions, transition structures, and intermediate products, leading to the final products, were optimized using the B3LYP functional with the 6-31G(d) basis set and the structures of the products were elucidated by 1D and 2D NMR experiments.
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Synthesis, characterization, DNA-binding studies and acetylcholinesterase inhibition activity of new 3-formyl chromone derivatives
TL;DR: A series of new substituted 3-formyl chromone derivatives (4-6) were synthesized by one step reaction methodology by knoevenagel condensation, structurally similar to known bisintercalators and it was found that synthesized compounds, especially compound 6 (evident from binding constant value) bind strongly with calf thymus DNA, presumably via an intercalation mode.
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Reactions of 3-acylchromones with dimethyl 1,3-acetonedicarboxylate and 1,3-diphenylacetone: one-pot synthesis of functionalized 2-hydroxybenzophenones, 6H-benzo[c]chromenes and benzo[c]coumarins.
Viktor O. Iaroshenko,Viktor O. Iaroshenko,Iryna Savych,Alexander Villinger,Vyacheslav Ya. Sosnovskikh,Peter Langer +5 more
TL;DR: The compounds synthesized can be considered as promising scaffolds for the design of the novel UV-A/B and UV-B filters.
Journal ArticleDOI
Synthesis of functionalized 2-salicyloylfurans, furo[3,2-b]chromen-9-ones and 2-benzoyl-8H-thieno[2,3-b]indoles by one-pot cyclizations of 3-halochromones with β-ketoamides and 1,3-dihydroindole-2-thiones
Iryna Savych,Tim Gläsel,Alexander Villinger,Vyacheslav Ya. Sosnovskikh,Viktor O. Iaroshenko,Viktor O. Iaroshenko,Viktor O. Iaroshenko,Peter Langer,Peter Langer +8 more
TL;DR: The cyclization reactions reported herein are mechanistically surprising as they proceed via the oxygen and not via the (more nucleophilic) nitrogen atom of the β-ketoamide.
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Studies on the Chemical Transformations of 6-Methylchromone-3-carbonitrile under Nucleophilic Conditions
TL;DR: In this paper, the chemical reactivity of 6-methylchromone-3-carbonitrile (1) was studied towards some nucleophilic reagents, including 3-amino-1,2,4-triazole, 2-aminobenzimidazole and 7-chloro-4-hydrazinoquinoline.
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Journal ArticleDOI
Facile Oxidation of Aldehydes to Acids and Esters with Oxone
TL;DR: A highly efficient, mild, and simple protocol is presented for the oxidation of aldehydes to carboxylic acids utilizing Oxone as the sole oxidant.
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Synthesis, Biological Evaluation, and Quantitative Structure−Activity Relationship Analysis of New Schiff Bases of Hydroxysemicarbazide as Potential Antitumor Agents†
Shijun Ren,Rubin Wang,Kenichi Komatsu,Patricia Bonaz-Krause,Yegor Zyrianov,Charles E. McKenna,Csaba Csipke,Zoltán A. Tökés,Eric J. Lien +8 more
TL;DR: Quantitative structure-activity relationship (QSAR) analysis showed that, besides the essential pharmacophore (-NHCONHOH), hydrophobicity, molecular size/polarizability, and the presence of an oxygen-containing group at the ortho position (I) were important determinants for the antitumor activities.
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Studies on antianaphylactic agents—III
TL;DR: By the application of the Vilsmeier-Haack reaction to various o-hydroxyacetophenone derivatives, 4-oxo-4H-1-benzopyran-3-carboxaldehydes were synthesized in one step as discussed by the authors.
Journal ArticleDOI
Knoevenagel condensation reactions in an ionic liquid
TL;DR: In this paper, the condensation reaction of 4-oxo-(4H)-1-benzopyran-3-carbaldehydes and of aromatic aldehydes with 3-methyl-1-phenylpyrazolin-5-4H-one were carried out in an ionic liquid, ethylammonium nitrate, at room temperature in shorter times with higher yields of 78−92 and 70−75%, respectively, than found using conventional procedures.
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Design, synthesis, and evaluation of novel 6-chloro-/fluorochromone derivatives as potential topoisomerase inhibitor anticancer agents.
TL;DR: The compounds displayed promising anticancer activity under these test systems and shall serve as useful 'leads' for further design.