Journal ArticleDOI
CHOP mediates XBP1S-induced renal mesangial cell necrosis following high glucose treatment
TLDR
It is suggested that XBP1S protected MCs from HG-induced apoptosis and necrosis, and CHOP participates in X BP1S-regulated necrosis but not apoptosis.About:
This article is published in European Journal of Pharmacology.The article was published on 2015-07-05. It has received 17 citations till now. The article focuses on the topics: CHOP & Necrosis.read more
Citations
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BRD7 Mediates Hyperglycaemia-Induced Myocardial Apoptosis via Endoplasmic Reticulum Stress Signalling Pathway
Xiaomeng Wang,Ying-cui Wang,Xiangjuan Liu,Qi Wang,Chun-mei Zhang,Li-ping Zhang,Hui Liu,Xinyu Zhang,Yang Mao,Zhiming Ge +9 more
TL;DR: In conclusion, inhibition of BRD7 appeared to protect against hyperglycaemia‐induced cardiomyocyte apoptosis by inhibiting ER stress signalling pathway.
Journal ArticleDOI
KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.
TL;DR: It is found that downregulation and functional inhibition of KPNB1 in glioblastoma cells induced growth arrest and apoptosis without apparent mitotic arrest and that rebalance of cytosolic/nuclear protein distribution and alleviate of protein overload favor proteostasis and cell survival.
Journal ArticleDOI
Atf6α impacts cell number by influencing survival, death and proliferation
TL;DR: Current knowledge of the basic biology of Atf6α is summarized, along with the pleiotropic roles Atf 6α plays in cell life and death decisions and possible explanations for conflicting observations, to help clarify the many gaps in understanding.
Journal ArticleDOI
Alpha-mangostin attenuates diabetic nephropathy in association with suppression of acid sphingomyelianse and endoplasmic reticulum stress.
Tingting Liu,Wang Duan,Paul Nizigiyimana,Lin Gao,Zhouning Liao,Boya Xu,Lerong Liu,Minxiang Lei +7 more
TL;DR: Alpha-mangostin, an acid sphingomyelinase inhibitor plays a protective role in diabetic neuropathy by relieving ER stress induced-renal cell apoptosis and down-regulated the expression of ER stress-related proteins in association with decreased levels of diabetic kidney injury.
Journal ArticleDOI
Altered DNA methylation of TRIM13 in diabetic nephropathy suppresses mesangial collagen synthesis by promoting ubiquitination of CHOP.
TL;DR: It is demonstrated that overexpressed TRIM13 suppresses mesangial collagen synthesis in DN by promoting ubiquitination of CHOP, suggesting TRIM 13 as a potential therapeutic target in treating DN.
References
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Journal ArticleDOI
Mitochondrial Membrane Permeabilization in Cell Death
TL;DR: Once MMP has been induced, it causes the release of catabolic hydrolases and activators of such enzymes (including those of caspases) from mitochondria, meaning that mitochondria coordinate the late stage of cellular demise.
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How dying cells alert the immune system to danger
Hajime Kono,Kenneth L. Rock +1 more
TL;DR: Current knowledge of cell death and repair processes in the host and their importance to host defence and disease pathogenesis has only been appreciated relatively recently is reviewed.
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The role for endoplasmic reticulum stress in diabetes mellitus.
TL;DR: This review addresses the transition from physiology to pathology, namely how and why the physiological UPR evolves to a proapoptotic ER stress response and which defenses are triggered by beta-cells against these challenges.
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Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway
Junichi Hitomi,Dana E. Christofferson,Aylwin Ng,Jianhua Yao,Alexei Degterev,Ramnik J. Xavier,Junying Yuan +6 more
TL;DR: A cellular signaling network that regulates necroptosis and the molecular bifurcation that controls apoptosis and ne croptosis is defined and it is shown that the expression of subsets of the 432 genes is enriched in the immune and nervous systems, and cellular sensitivity to necroPTosis is regulated by an extensive signaling network mediating innate immunity.
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XBP1 Controls Diverse Cell Type- and Condition-Specific Transcriptional Regulatory Networks
Diego Acosta-Alvear,Yiming Zhou,Alexandre Blais,Mary Tsikitis,Nathan H. Lents,Carolina Arias,Christen J. Lennon,Yuval Kluger,Brian David Dynlacht +8 more
TL;DR: A core group of genes involved in constitutive maintenance of ER function in all cell types and tissue- and condition-specific targets are identified and a cadre of unexpected targets that link XBP1 to neurodegenerative and myodegenerative diseases, as well as to DNA damage and repair pathways are identified.