Journal ArticleDOI
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
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TLDR
It is proposed that this chemical selectively damages cells in the substantia nigra in patients who developed marked parkinsonism after using an illicit drug intravenously.Abstract:
Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in the substantia nigra.read more
Citations
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Cell death pathways in Parkinson's disease: role of mitochondria.
Zhi Yao,Nicholas W. Wood +1 more
TL;DR: An overview of the role of mitochondria in the pathogenesis of both sporadic and familial forms of PD is provided and novel therapeutic opportunities which target mitochondria are highlighted.
Journal ArticleDOI
Toxicity of 1-methyl-4-phenylpyridinium for rat dopaminergic neurons in culture: selectivity and irreversibility.
TL;DR: Evidence is provided that MPP+ treatment results in highly selective and irreversible toxicity for cultured dopaminergic neurons and that no recovery was seen after posttreatment incubation in toxin‐free medium.
Journal ArticleDOI
Mitochondrial dysfunction in genetic animal models of Parkinson's disease.
TL;DR: The evidence for mitochondrial dysfunction in genetic animal models of Parkinson's disease is critically discussed, and whether abnormal mitochondrial function represents a cause or consequence of disease pathogenesis is evaluated.
Journal ArticleDOI
Brain insulin resistance: role in neurodegenerative disease and potential for targeting.
TL;DR: Novel dual GLP-1/GIP receptor agonists that cross the blood brain barrier show superior neuroprotective effects compared to single GLP -1 or GIP receptors agonists, and show great promise as novel treatments of AD and PD.
Journal ArticleDOI
Targeting mitochondrial dysfunction in neurodegenerative disease: Part II.
Victoria S Burchell,Sonia Gandhi,Emma Deas,Nicholas W. Wood,Andrey Y. Abramov,Helene Plun-Favreau +5 more
TL;DR: This review examines the role of mitochondrial dysfunction in neurodegeneration, drawing examples from common diseases such as Alzheimer's disease and rarer familial disorders such as Charcot-Marie-Tooth.
References
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Journal ArticleDOI
Chronic Parkinsonism secondary to intravenous injection of meperidine analogues.
Glenn C. Davis,Adrian C. Williams,Sanford P. Markey,Michael H. Ebert,Eric D. Caine,Cheryl M. Reichert,Irwin J. Kopin +6 more
TL;DR: Biogenic amines and metabolites in the cerebrospinal fluid and microscopic evaluation of the brain at necropsy were consistent with damage to aminergic neurons in the substantia nigra.
Journal ArticleDOI
Apraxia of lid opening
Jack E. Goldstein,David G. Cogan +1 more
TL;DR: Apraxia of lid opening is a nonparalytic motor abnormality characterized by the patient's difficulty in initiating the act of lid elevation and differs from paralytic ptosis by being present only momentarily at the start of lidOpening.
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