Journal ArticleDOI
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
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TLDR
It is proposed that this chemical selectively damages cells in the substantia nigra in patients who developed marked parkinsonism after using an illicit drug intravenously.Abstract:
Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in the substantia nigra.read more
Citations
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MicroRNA-7 Regulates the Function of Mitochondrial Permeability Transition Pore by Targeting VDAC1 Expression
TL;DR: In this paper, the expression of voltage-dependent anion channel 1 (VDAC1), a constituent of the mitochondrial permeability transition pore, was downregulated by microRNA-7 through targeting 3'-untranslated region of VDAC1 mRNA.
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'Designer drugs'. A problem in clinical toxicology.
TL;DR: The most extensively studied class of psychoactive compounds is the phenylethylamines (mescaline analogues), which includes catecholamines, therapeutic agents and numerous illicit derivatives.
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Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review.
TL;DR: Future technological developments alongside with a deeper understanding of the molecular bases of these disorders should enable the development of novel zebrafish lines that can prove useful for drug discovery for movement disorders.
Journal ArticleDOI
Treatment with GM1 ganglioside restores striatal dopamine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse.
TL;DR: The biochemical findings in animals suggest that early GM1 ganglioside treatment of individuals with degenerative diseases of dopaminergic nigrostriatal neurons might be fruitful, and this dosage regimen resulted in an ∼50% reduction of striatal dopamine level.
Journal ArticleDOI
Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity by 1-methyl-4-phenylpyridinium ion.
TL;DR: Effect of 1-methyl-4-phenylpyridinium ion (MPP+) on the activity of NADH-ubiquinone oxidoreductase was studied using mitochondria prepared from rat brains and importance was discussed with respect to the mechanism of neuronal degeneration by MPP+.
References
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Journal ArticleDOI
Chronic Parkinsonism secondary to intravenous injection of meperidine analogues.
Glenn C. Davis,Adrian C. Williams,Sanford P. Markey,Michael H. Ebert,Eric D. Caine,Cheryl M. Reichert,Irwin J. Kopin +6 more
TL;DR: Biogenic amines and metabolites in the cerebrospinal fluid and microscopic evaluation of the brain at necropsy were consistent with damage to aminergic neurons in the substantia nigra.
Journal ArticleDOI
Apraxia of lid opening
Jack E. Goldstein,David G. Cogan +1 more
TL;DR: Apraxia of lid opening is a nonparalytic motor abnormality characterized by the patient's difficulty in initiating the act of lid elevation and differs from paralytic ptosis by being present only momentarily at the start of lidOpening.
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