Journal ArticleDOI
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
Reads0
Chats0
TLDR
It is proposed that this chemical selectively damages cells in the substantia nigra in patients who developed marked parkinsonism after using an illicit drug intravenously.Abstract:
Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in the substantia nigra.read more
Citations
More filters
Journal ArticleDOI
Differential expression of two vesicular monoamine transporters
TL;DR: Although adrenal chromaffin cells, sympathetic and enteric neurons derive from the neural crest, they express different vesicular amine transporters, these findings are consistent with the functional characteristics of VMAT1 and VMAT2 and help to explain several classic pharmacological observations.
Journal ArticleDOI
Complex I and Parkinson's disease.
TL;DR: Chronic rotenone exposure accurately recapitulated the pathological, biochemical, and behavioral features of PD, suggesting relatively subtle complex I abnormalities‐‐either genetic or acquired‐‐may be central to the pathogenesis of PD.
Journal ArticleDOI
The History of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies
TL;DR: Historically important anatomical, biochemical, and physiological studies identified additional pharmacological and neurosurgical targets for Parkinson's disease and allow modern clinicians to offer an array of therapies aimed at improving function in this still incurable disease.
Journal ArticleDOI
Glutamate and Parkinson's disease
TL;DR: The involvement of the glutamatergic system in the pathogenesis and symptomatology of PD provides potential new targets for therapeutic intervention in this neuro-degenerative disorder.
Journal ArticleDOI
Role of oxidative stress and antioxidants in neurodegenerative diseases.
A.V. Rao,B. Balachandran +1 more
TL;DR: The pathobiology of neurodegenerative disorders with emphasis on genetic origin and its correlation with oxidative stress of neuro degenerative disorders will be reviewed and the reasons as to why brain constitutes a vulnerable site of oxidative damage will be discussed.
References
More filters
Journal ArticleDOI
Chronic Parkinsonism secondary to intravenous injection of meperidine analogues.
Glenn C. Davis,Adrian C. Williams,Sanford P. Markey,Michael H. Ebert,Eric D. Caine,Cheryl M. Reichert,Irwin J. Kopin +6 more
TL;DR: Biogenic amines and metabolites in the cerebrospinal fluid and microscopic evaluation of the brain at necropsy were consistent with damage to aminergic neurons in the substantia nigra.
Journal ArticleDOI
Apraxia of lid opening
Jack E. Goldstein,David G. Cogan +1 more
TL;DR: Apraxia of lid opening is a nonparalytic motor abnormality characterized by the patient's difficulty in initiating the act of lid elevation and differs from paralytic ptosis by being present only momentarily at the start of lidOpening.
Related Papers (5)
Mutation in the α-synuclein gene identified in families with Parkinson's disease
Mihael H. Polymeropoulos,Christian Lavedan,Elisabeth Leroy,Susan E. Ide,Anindya Dehejia,Amalia Dutra,Brian L. Pike,Holly Root,Jeffrey Rubenstein,Rebecca Boyer,Edward S. Stenroos,Settara C. Chandrasekharappa,Aglaia Athanassiadou,Theodore Papapetropoulos,William G. Johnson,Alice Lazzarini,Roger C. Duvoisin,Giuseppe Di Iorio,Lawrence I. Golbe,Robert L. Nussbaum +19 more