Journal ArticleDOI
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
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TLDR
It is proposed that this chemical selectively damages cells in the substantia nigra in patients who developed marked parkinsonism after using an illicit drug intravenously.Abstract:
Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in the substantia nigra.read more
Citations
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The gestational environment and Parkinson's disease: evidence for neurodevelopmental origins of a neurodegenerative disorder.
Brian K. Barlow,Deborah A. Cory-Slechta,Deborah A. Cory-Slechta,Eric K. Richfield,Mona Thiruchelvam,Mona Thiruchelvam +5 more
TL;DR: In this review, three animal models are described for potential relevance in linking PD with the Fetal Basis of Adult Disease (FeBAD) hypothesis and challenges in studying the neurodevelopmental basis of neurodegeneration experimentally and epidemiologically are presented.
Journal ArticleDOI
Parkinson's disease: genetic versus toxin-induced rodent models.
Mügen Terzioglu,Dagmar Galter +1 more
TL;DR: Three types of rodent animal models used to study different aspects of PD are compared: animal models using neurotoxins; genetically modified mouse models reproducing findings from PD linkage studies or based on ablation of genes necessary for the development and survival of dopamine neurons; and (c) tissue‐specific knockouts in mice targeting dopamine neurons.
Journal ArticleDOI
Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson's disease
Kotaro Kida,Marina Yamada,Marina Yamada,Kentaro Tokuda,Eizo Marutani,Manabu Kakinohana,Masao Kaneki,Masao Kaneki,Fumito Ichinose +8 more
TL;DR: It is suggested that inhaled H(2)S prevents neurodegeneration in a mouse model of Parkinson's disease induced by MPTP, potentially via upregulation of antioxidant defense mechanisms and inhibition of inflammation and apoptosis in the brain.
Journal ArticleDOI
Advances in porcine genomics and proteomics—a toolbox for developing the pig as a model organism for molecular biomedical research
TL;DR: The aim of this review is to highlight the current progress of these ongoing areas of research, which are mandatory for successful development of biomedical pig models that are in demand for understanding human biology in health and disease.
Journal ArticleDOI
Positron emission tomographic evidence for progression of human MPTP-induced dopaminergic lesions.
Francois J. G. Vingerhoets,Barry J. Snow,J Tetrud,J. W. Langston,Michael Schulzer,D. B. Calne +5 more
TL;DR: The findings support the hypothesis that some neurodegenerative disorders may result from transient exposure to an environmental agent and suggest that short‐term exposure to MPTP leads to a protracted decline in nigrostriatal dopaminergic function more rapid than occurs in normal aging and similar to IP progression.
References
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Journal ArticleDOI
Chronic Parkinsonism secondary to intravenous injection of meperidine analogues.
Glenn C. Davis,Adrian C. Williams,Sanford P. Markey,Michael H. Ebert,Eric D. Caine,Cheryl M. Reichert,Irwin J. Kopin +6 more
TL;DR: Biogenic amines and metabolites in the cerebrospinal fluid and microscopic evaluation of the brain at necropsy were consistent with damage to aminergic neurons in the substantia nigra.
Journal ArticleDOI
Apraxia of lid opening
Jack E. Goldstein,David G. Cogan +1 more
TL;DR: Apraxia of lid opening is a nonparalytic motor abnormality characterized by the patient's difficulty in initiating the act of lid elevation and differs from paralytic ptosis by being present only momentarily at the start of lidOpening.
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