Journal ArticleDOI
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
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TLDR
It is proposed that this chemical selectively damages cells in the substantia nigra in patients who developed marked parkinsonism after using an illicit drug intravenously.Abstract:
Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in the substantia nigra.read more
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Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance
Bavo Heeman,Chris Van den Haute,Sarah-Ann Aelvoet,Federica Valsecchi,Richard J. Rodenburg,Veerle Reumers,Zeger Debyser,Geert Callewaert,Werner J.H. Koopman,Peter H.G.M. Willems,Veerle Baekelandt +10 more
TL;DR: A key role for PINK1 is demonstrated in the regulation of mitochondrial homeostasis and energy metabolism under physiological conditions, and the impairment in energy maintenance was confirmed in the brain of Pink1-knockout mice by in vivo bioluminescence imaging.
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Vesicular monoamine transporters: Structure‐function, pharmacology, and medicinal chemistry
TL;DR: In this paper, a review summarizes the current understanding of the structure-function relationships of VMAT2, and the role of VAT2 on addiction and psychostimulant induced neurotoxicity.
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Neuroprotective Effect of Ghrelin in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson’s Disease by Blocking Microglial Activation
Minho Moon,Hyo Geun Kim,Lakkyong Hwang,Ji-Hyung Seo,Sehee Kim,Sunyoung Hwang,Soonyong Kim,Dahm Lee,Hyunju Chung,Myung Sook Oh,Kyung-Tae Lee,Seungjoon Park +11 more
TL;DR: The data indicate that ghrelin may act as a survival factor for dopaminergic neurons by functioning as a microglia-deactivating factor and suggest that gh Relin may be a valuable therapeutic agent for neurodegenerative diseases such as PD.
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In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?
TL;DR: Each animal model based on alpha-synuclein overexpression reproduces a subset of features of PD and can be used to identify therapeutic targets and test disease-modifying therapies, but the predictive value remains speculative in the absence of effective neuroprotective treatments for PD in humans.
Journal ArticleDOI
Targeting Alpha-Synuclein as a Therapy for Parkinson's Disease.
TL;DR: Current advances in therapeutic efforts for PD that aim to produce a disease-modifying therapy by targeting the spread, production, aggregation, and degradation of alpha-synuclein are reviewed.
References
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Journal ArticleDOI
Chronic Parkinsonism secondary to intravenous injection of meperidine analogues.
Glenn C. Davis,Adrian C. Williams,Sanford P. Markey,Michael H. Ebert,Eric D. Caine,Cheryl M. Reichert,Irwin J. Kopin +6 more
TL;DR: Biogenic amines and metabolites in the cerebrospinal fluid and microscopic evaluation of the brain at necropsy were consistent with damage to aminergic neurons in the substantia nigra.
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Apraxia of lid opening
Jack E. Goldstein,David G. Cogan +1 more
TL;DR: Apraxia of lid opening is a nonparalytic motor abnormality characterized by the patient's difficulty in initiating the act of lid elevation and differs from paralytic ptosis by being present only momentarily at the start of lidOpening.
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