Journal ArticleDOI
Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression.
Dan Han,Jiangxue Li,Huamin Wang,Xiaoping Su,Jin Hou,Yan Gu,Cheng Qian,Yun Lin,Xiang Liu,Mingyan Huang,Nan Li,Weiping Zhou,Yizhi Yu,Xuetao Cao +13 more
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TLDR
In this article, the expression profile and function of circRNAs in human hepatocellular carcinoma (HCC) remain to be investigated, and the authors used a biotin-labeled circMTO1 probe to perform RNA in vivo precipitation in HCC cells.About:
This article is published in Hepatology.The article was published on 2017-10-01. It has received 862 citations till now. The article focuses on the topics: microRNA & Mitochondrial translation.read more
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Circular RNA MTO1 suppresses tumorigenesis of gastric carcinoma by sponging miR‐3200-5p and targeting PEBP1
TL;DR: This study was the first to indagate the underlying mechanism of circMTO1 in GC and confirmed circM to1 exerted its anti-cancer effects by miR-3200-5p/PEBP1 axis, implying that circMto1 may become a new promising therapeutic target for GC patients.
Journal ArticleDOI
Hypoxia induces the activation of hepatic stellate cells through the PVT1-miR-152-ATG14 signaling pathway
TL;DR: It is demonstrated that plasmacytoma variant translocation 1 (PVT1) and autophagy were overexpressed in liver fibrotic specimens and contributes to activation of HSCs under hypoxia condition.
Journal ArticleDOI
Down-regulation of circ-PRKCI inhibits cell migration and proliferation in Hirschsprung disease by suppressing the expression of miR-1324 target PLCB1.
Lingling Zhou,Yang Li,Weiwei Jiang,Hua Zhang,Zechao Wen,Yang Su,Feng Wu,Zhengke Zhi,Qiyang Shen,Hongxing Li,Xiaoqun Xu,Weibing Tang +11 more
TL;DR: The important role of circ-PRKCI-miR-1324-PLCB1 regulatory network in HSCR is revealed, providing a novel insight for the pathogenesis of H SCR.
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Circular RNA circ-CSPP1 regulates CCNE2 to facilitate hepatocellular carcinoma cell growth via sponging miR-577
TL;DR: It is revealed that circ-CSPP1 contributed to HCC progression by positively regulating CCNE2 via miR-577, thus established its potential as new a prognostic and therapeutic marker for HCC patients.
Journal ArticleDOI
Circular RNA in Schizophrenia and Depression.
TL;DR: The classification, characteristics, and biological functions of circ RNA, as an important component of ncRNA, and the most significant results of experimental studies are summarized, aiming to highlight the involvement of circRNA in SZ and DEP.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
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Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
Journal ArticleDOI
MicroRNA gene expression deregulation in human breast cancer.
Marilena V. Iorio,Manuela Ferracin,Chang Gong Liu,Angelo Veronese,Riccardo Spizzo,Silvia Sabbioni,Eros Magri,Massimo Pedriali,Muller Fabbri,Manuela Campiglio,Sylvie Ménard,Juan P. Palazzo,Anne L. Rosenberg,Piero Musiani,Stefano Volinia,Italo Nenci,George A. Calin,Patrizia Querzoli,Massimo Negrini,Carlo M. Croce +19 more
TL;DR: It is shown that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer, and the overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated mi RNAs being mir-125b, mir-145, mir -21, and mir-155.