Journal ArticleDOI
Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression.
Dan Han,Jiangxue Li,Huamin Wang,Xiaoping Su,Jin Hou,Yan Gu,Cheng Qian,Yun Lin,Xiang Liu,Mingyan Huang,Nan Li,Weiping Zhou,Yizhi Yu,Xuetao Cao +13 more
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TLDR
In this article, the expression profile and function of circRNAs in human hepatocellular carcinoma (HCC) remain to be investigated, and the authors used a biotin-labeled circMTO1 probe to perform RNA in vivo precipitation in HCC cells.About:
This article is published in Hepatology.The article was published on 2017-10-01. It has received 862 citations till now. The article focuses on the topics: microRNA & Mitochondrial translation.read more
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CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression.
TL;DR: CircSLC3A2 acts as an oncogenic factor in HCC by sponging miR-490-3p and regulating PPM1F expression, and harbored a positive correlation with poor survival in patients with HCC.
Journal Article
Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506.
TL;DR: Investigation of the expression profiles and potential modulation of circRNA on cervical cancer carcinogenesis found that circRNA-000284 promotes cell proliferation and invasion in cervical cancer, and may serve as a promising therapeutic target for cervical cancer patients.
Journal ArticleDOI
Epidemiological and etiological variations in hepatocellular carcinoma.
TL;DR: A substantial further reduction in cases of HCC requires a wider application of universal HBV vaccination and effective treatment of HBV- and HCV-related chronic hepatitis and cirrhosis, more effective campaigns to favor correct dietary habits and reduce alcohol consumption and the intensification of studies on HCC pathogenesis for future optimized prevention strategies.
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Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis
TL;DR: The findings indicate that circRNA-000911 plays an anti-oncogenic role in breast cancer and may thus serve as a promising therapeutic target for patients with breast cancer.
Journal ArticleDOI
Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression
Gehao Liang,Yun Ling,Maryam Mehrpour,Maryam Mehrpour,Phei Er Saw,Zihao Liu,Weige Tan,Zhenluan Tian,Wenjing Zhong,Wanyi Lin,Qing Luo,Qun Lin,Qiufang Li,You Zhou,You Zhou,Ahmed Hamaï,Ahmed Hamaï,Patrice Codogno,Patrice Codogno,Jun Li,Erwei Song,Chang Gong +21 more
TL;DR: Clinically, increasedcircCDYL in the tumor tissues and serum of BC patients was associated with higher tumor burden, shorter survival and poorer clinical response to therapy, and circCDYL could act as a potential prognostic and predictive molecule for breast cancer patients.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
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Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
Journal ArticleDOI
MicroRNA gene expression deregulation in human breast cancer.
Marilena V. Iorio,Manuela Ferracin,Chang Gong Liu,Angelo Veronese,Riccardo Spizzo,Silvia Sabbioni,Eros Magri,Massimo Pedriali,Muller Fabbri,Manuela Campiglio,Sylvie Ménard,Juan P. Palazzo,Anne L. Rosenberg,Piero Musiani,Stefano Volinia,Italo Nenci,George A. Calin,Patrizia Querzoli,Massimo Negrini,Carlo M. Croce +19 more
TL;DR: It is shown that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer, and the overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated mi RNAs being mir-125b, mir-145, mir -21, and mir-155.