Journal ArticleDOI
Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression.
Dan Han,Jiangxue Li,Huamin Wang,Xiaoping Su,Jin Hou,Yan Gu,Cheng Qian,Yun Lin,Xiang Liu,Mingyan Huang,Nan Li,Weiping Zhou,Yizhi Yu,Xuetao Cao +13 more
Reads0
Chats0
TLDR
In this article, the expression profile and function of circRNAs in human hepatocellular carcinoma (HCC) remain to be investigated, and the authors used a biotin-labeled circMTO1 probe to perform RNA in vivo precipitation in HCC cells.About:
This article is published in Hepatology.The article was published on 2017-10-01. It has received 862 citations till now. The article focuses on the topics: microRNA & Mitochondrial translation.read more
Citations
More filters
Journal ArticleDOI
The Prognostic and Predictive Significance of circRNA CDR1as in Tumor Progression
Fang Jian,Ren Yangyang,Xu Wei,Xu Jiadan,Li Na,Yang Peng,Bian Mao-hong,Niu Guoping,Pan Zhaoji +8 more
TL;DR: Cerebellar degeneration-related protein 1 antisense (CDR1as) is an important member of the circRNAs family, also known as cirs-7 Its main function in vivo is to act as a mir-7 sponge as mentioned in this paper.
Journal ArticleDOI
Clinicopathological-Associated Regulatory Network of Deregulated circRNAs in Hepatocellular Carcinoma
Jian Han,Thomas Thurnherr,Alexander Y. F. Chung,Brian K. P. Goh,Pierce K. H. Chow,Pierce K. H. Chow,Chung Yip Chan,Peng Chung Cheow,Ser Yee Lee,Tony Kiat Hon Lim,Samuel S. Chong,London L.P.J. Ooi,London L.P.J. Ooi,Caroline G.L. Lee +13 more
TL;DR: In this article, the authors presented a novel strategy to identify key circRNA signatures of clinically relevant co-expressed circRNA-mRNA networks in pertinent cancerpathways that modulate prognosis of HCC patients, by integrating clinic-pathological features, circRNA and mRNA expression profiles.
Journal ArticleDOI
Circular RNA circ_GLIS2 suppresses hepatocellular carcinoma growth and metastasis
TL;DR: In this article, the authors investigated the molecular mechanism of hepatocellular carcinoma (HCC) by studying the function of circ_GLIS2 and found that over-expression of circ-glis2 and linear GLIS2 suppressed HCC cell proliferation, migration, and invasion but promoted cell apoptosis.
Journal ArticleDOI
New challenges for microRNAs in acute pancreatitis: progress and treatment
TL;DR: In this paper , the relationship between miRNAs and acute pancreatitis is reviewed, and the current research on the relationship is discussed, as well as the diagnosis and treatment of AP.
Journal ArticleDOI
Regulation of MRP4 Expression by circHIPK3 via Sponging miR-124-3p/miR-4524-5p in Hepatocellular Carcinoma.
Haihong Hu,Yu Wang,Zhiyuan Qin,Wen Sun,Yanhong Chen,Jiaqi Wang,Yingying Wang,Jing Nie,Lu Chen,Sheng Cai,Lushan Yu,Su Zeng +11 more
TL;DR: In this article, the role of miRNAs in downregulating the expression of multidrug resistance-associated protein 4 (MRP4) was investigated, and it was shown that miR-4524-5p and circHIPK3 inhibited MRP4 at the protein level but not mRNA level.
References
More filters
Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
Journal ArticleDOI
Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
Journal ArticleDOI
MicroRNA gene expression deregulation in human breast cancer.
Marilena V. Iorio,Manuela Ferracin,Chang Gong Liu,Angelo Veronese,Riccardo Spizzo,Silvia Sabbioni,Eros Magri,Massimo Pedriali,Muller Fabbri,Manuela Campiglio,Sylvie Ménard,Juan P. Palazzo,Anne L. Rosenberg,Piero Musiani,Stefano Volinia,Italo Nenci,George A. Calin,Patrizia Querzoli,Massimo Negrini,Carlo M. Croce +19 more
TL;DR: It is shown that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer, and the overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated mi RNAs being mir-125b, mir-145, mir -21, and mir-155.