Journal ArticleDOI
Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression.
Dan Han,Jiangxue Li,Huamin Wang,Xiaoping Su,Jin Hou,Yan Gu,Cheng Qian,Yun Lin,Xiang Liu,Mingyan Huang,Nan Li,Weiping Zhou,Yizhi Yu,Xuetao Cao +13 more
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TLDR
In this article, the expression profile and function of circRNAs in human hepatocellular carcinoma (HCC) remain to be investigated, and the authors used a biotin-labeled circMTO1 probe to perform RNA in vivo precipitation in HCC cells.About:
This article is published in Hepatology.The article was published on 2017-10-01. It has received 862 citations till now. The article focuses on the topics: microRNA & Mitochondrial translation.read more
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Mining Database for the Expression and Clinical Significance of NF-κB Family in Hepatocellular Carcinoma.
TL;DR: RelB and NF-κB2 are potential biomarkers for the diagnosis, prognosis, and immunotherapy of HCC and had a worse overall survival and disease-free survival than normal liver tissues.
Journal ArticleDOI
CircSTK40 contributes to recurrent implantation failure via modulating the HSP90/AKT/FOXO1 axis.
TL;DR: In this paper, the role of circular RNAs (circRNAs) in recurrent implantation failure (RIF) remains largely unknown, however, recent evidence has revealed a close relationship between non-coding RNAs and recurrent infection failure.
Journal ArticleDOI
Circular RNA circ_0008305 aggravates hepatocellular carcinoma growth through binding to miR‐186 and inducing TMED2
Xiao-Yu Zhang,Hui-Hui Hao,Hai-Wen Zhuang,Jian Wang,Yu Sheng,Fang Xu,Jin Dou,Chuang Chen,Yang Shen +8 more
TL;DR: Mechanistically, it is demonstrated that circ_0008305 up‐regulated TMED2 expression by sponging miR‐186, which resulted in significantly induced HCC progression in vitro and in vivo, which might indicate a new perspective on circRNAs in HCC development.
Journal ArticleDOI
Identification of differentially expressed circular RNAs in human nasopharyngeal carcinoma.
Hanwei Wu,Yuchen Liu,Hongfang Duan,Hongfang Duan,Xiaoqin Fan,Yujie Wang,Jian Song,Jinghong Han,Ming Yang,Lu Lu,Guohui Nie +10 more
TL;DR: The results show that hsa_circ_0007637 may be a biomarker for NPC and play a role in its development, and quantitative real-time PCR was utilized to verify dysregulated circRNAs in NPC.
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The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma
TL;DR: The regulatory roles of ncRNAs in glucose, lipid and amino acid metabolism are elaborated and possible therapeutic strategies that target the metabolism of cancer cells by modulating the expressions of specific nc RNAs are discussed.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
Journal ArticleDOI
Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
Journal ArticleDOI
MicroRNA gene expression deregulation in human breast cancer.
Marilena V. Iorio,Manuela Ferracin,Chang Gong Liu,Angelo Veronese,Riccardo Spizzo,Silvia Sabbioni,Eros Magri,Massimo Pedriali,Muller Fabbri,Manuela Campiglio,Sylvie Ménard,Juan P. Palazzo,Anne L. Rosenberg,Piero Musiani,Stefano Volinia,Italo Nenci,George A. Calin,Patrizia Querzoli,Massimo Negrini,Carlo M. Croce +19 more
TL;DR: It is shown that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer, and the overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated mi RNAs being mir-125b, mir-145, mir -21, and mir-155.