Journal ArticleDOI
Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression.
Dan Han,Jiangxue Li,Huamin Wang,Xiaoping Su,Jin Hou,Yan Gu,Cheng Qian,Yun Lin,Xiang Liu,Mingyan Huang,Nan Li,Weiping Zhou,Yizhi Yu,Xuetao Cao +13 more
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TLDR
In this article, the expression profile and function of circRNAs in human hepatocellular carcinoma (HCC) remain to be investigated, and the authors used a biotin-labeled circMTO1 probe to perform RNA in vivo precipitation in HCC cells.About:
This article is published in Hepatology.The article was published on 2017-10-01. It has received 862 citations till now. The article focuses on the topics: microRNA & Mitochondrial translation.read more
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Expression Profiling and Bioinformatics Analysis of CircRNA in Mice Brain Infected with Rabies Virus
TL;DR: In this article, the authors characterized the transcriptomic pattern of circRNAs, and signaling pathways and function that circRNA are involved in, which may indicate directions for further research to understand mechanisms of RABV pathogenesis.
Journal ArticleDOI
Carboxypeptidase E down-regulation regulates transcriptional and epigenetic profiles in pancreatic cancer cell line: A network analysis.
TL;DR: Down-regulation of CPE gene expression in PANC-1 cell showed that CPE down-regulation caused decreased cell proliferation, and Bioinformatics analysis showed that the top significantly enriched pathways for the differentially expressed RNAs were related to cancer onset and/or progression.
Journal ArticleDOI
The Roles of circMTO1 in Cancer
TL;DR: The CircRNA mitochondrial tRNA translation optimization 1 (circMTO1), a recently reported circular RNA originating from exons of MTO1 located on chromosome 6q13, was proved to be abnormally expressed in many malignant tumors, such as hepatocellular carcinoma, gastric carcinoma and colorectal cancer, resulting in tumor initiation and progression as discussed by the authors.
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The circ_0032822 Promotes the Proliferation of Head and Neck Squamous Cell Carcinoma Cells Through miR-141/EF3 Signaling Axis.
Shuajia Zhang,Jiahui Han,Jing Fu +2 more
TL;DR: In this article, the authors confirmed the upregulation of circ_0032822 in HNSCC tumor tissues and showed that the over-expansion and down-down regulation of the circ_3-2822 has the opposite effect in vitro.
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The hsa_circRNA_102049 mediates the sorafenib sensitivity of hepatocellular carcinoma cells by regulating Reelin gene expression
TL;DR: The results showed that RELN gene demethylation reversed the cytotoxic of sorafenib on HepG2 cells and Huh-7 cells, which support targeting of hsa_circRNA_102049 and RELN in sorAFenib-treated HCC cells as a novel intervention, which is expected to overcome sorafinib resistance of H CC cells.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
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Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
Journal ArticleDOI
MicroRNA gene expression deregulation in human breast cancer.
Marilena V. Iorio,Manuela Ferracin,Chang Gong Liu,Angelo Veronese,Riccardo Spizzo,Silvia Sabbioni,Eros Magri,Massimo Pedriali,Muller Fabbri,Manuela Campiglio,Sylvie Ménard,Juan P. Palazzo,Anne L. Rosenberg,Piero Musiani,Stefano Volinia,Italo Nenci,George A. Calin,Patrizia Querzoli,Massimo Negrini,Carlo M. Croce +19 more
TL;DR: It is shown that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer, and the overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated mi RNAs being mir-125b, mir-145, mir -21, and mir-155.