Journal ArticleDOI
Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression.
Dan Han,Jiangxue Li,Huamin Wang,Xiaoping Su,Jin Hou,Yan Gu,Cheng Qian,Yun Lin,Xiang Liu,Mingyan Huang,Nan Li,Weiping Zhou,Yizhi Yu,Xuetao Cao +13 more
Reads0
Chats0
TLDR
In this article, the expression profile and function of circRNAs in human hepatocellular carcinoma (HCC) remain to be investigated, and the authors used a biotin-labeled circMTO1 probe to perform RNA in vivo precipitation in HCC cells.About:
This article is published in Hepatology.The article was published on 2017-10-01. It has received 862 citations till now. The article focuses on the topics: microRNA & Mitochondrial translation.read more
Citations
More filters
Journal ArticleDOI
CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma.
TL;DR: In this article, the authors explored the role of pre-mRNA 3' end formation and cleavage in circRNA formation and found that CPSF4 acts as an oncogene in HCC through circRNA inhibition and disruption of miRNA-mediated gene silencing.
Journal ArticleDOI
RNA sequencing reveals the expression profiles of circRNA and identifies a four-circRNA signature acts as a prognostic marker in esophageal squamous cell carcinoma
Weiwei Wang,Di Zhu,Zhihua Zhao,Miaomiao Sun,Feng Wang,Wencai Li,Jianying Zhang,Guozhong Jiang +7 more
TL;DR: Wang et al. as discussed by the authors identified prognostic circRNAs and constructed a circRNA-related signature in esophageal squamous cell carcinoma (ESCC) using RNA sequencing.
Journal ArticleDOI
CircRNA UBAP2 serves as a sponge of miR-1294 to increase tumorigenesis in hepatocellular carcinoma through regulating c-Myc expression.
Min-Cheng Yu,Guang-Yu Ding,Peng Ma,Yue-Da Chen,Xiao-Dong Zhu,Jia-Bin Cai,Ying-Hao Shen,Jian Zhou,Jia Fan,Hui-Chuan Sun,Ming Kuang,Cheng Huang +11 more
TL;DR: The findings suggest that circUBAP2 promotes HCC growth and metastasis and may have value as an independent prognostic biomarker or as a new target for the treatment of HCC.
Journal ArticleDOI
The Role of miRNA in Regulating the Fate of Monocytes in Health and Cancer
TL;DR: The current understanding of the role of small regulatory miRNA in monocyte formation, maturation and function in health and cancer development is summarized.
Journal ArticleDOI
CircRNA ZNF609 promotes the growth and metastasis of thyroid cancer in vivo and in vitro by downregulating miR-514a-5p
Ping Shi,Yang Liu,DongQiang Lin Wei Shi QiCi Wu RuiQi Yang,Yan-li Wu,Lan Zhang,Shanghua Jing,Huijing Shi,Cuizhi Geng +7 more
TL;DR: The findings highlighted the importance of circ-ZNF609 function in facilitating TC cell development and metastasis in vitro and in vivo via binding to miR-514a-5p.
References
More filters
Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
Journal ArticleDOI
Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
Journal ArticleDOI
MicroRNA gene expression deregulation in human breast cancer.
Marilena V. Iorio,Manuela Ferracin,Chang Gong Liu,Angelo Veronese,Riccardo Spizzo,Silvia Sabbioni,Eros Magri,Massimo Pedriali,Muller Fabbri,Manuela Campiglio,Sylvie Ménard,Juan P. Palazzo,Anne L. Rosenberg,Piero Musiani,Stefano Volinia,Italo Nenci,George A. Calin,Patrizia Querzoli,Massimo Negrini,Carlo M. Croce +19 more
TL;DR: It is shown that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer, and the overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated mi RNAs being mir-125b, mir-145, mir -21, and mir-155.