Comprehensive Meta-analysis of Key Immune-Related Adverse Events from CTLA-4 and PD-1/PD-L1 Inhibitors in Cancer Patients
Guillermo de Velasco,Youjin Je,Dominick Bossé,Mark M. Awad,Patrick A. Ott,Raphael Brandao Moreira,Fabio A.B. Schutz,Joaquim Bellmunt,Guru Sonpavde,F. Stephen Hodi,Toni K. Choueiri +10 more
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TLDR
There is substantial evidence that ICIs are associated with a small but significant increase in risk of selected all-grade irAEs and high-grade gastrointestinal and liver toxicities, and AEs should be recognized promptly as early interventions may alleviate future complications.Citations
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Associations of influenza vaccination with severity of immune-related adverse events in patients with advanced thoracic cancers on immune checkpoint inhibitors
Emily Pei-Ying Lin,Li Ching Huang,Jennifer G. Whisenant,Sally York,Travis J. Osterman,Jennifer Anne Lewis,Wade T. Iams,Emily Skotte,Amanda S Cass,Chih-Yuan Hsu,Yu Shyr,Leora Horn +11 more
TL;DR: This study showed that FV does not increase toxicity for patients with advanced thoracic cancer on ICIs and is associated with a decreased risk for grade 3–5 IRAEs and better survival times.
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Programmed death 1 (PD‐1) and ligand (PD‐L1) inhibitors in head and neck squamous cell carcinoma: A meta‐analysis
Dylan A. Levy,Jaimin Patel,Shaun A. Nguyen,W. Nicholas Jungbauer,David M. Neskey,Ezra E.W. Cohen,Chrystal M. Paulos,John A. Kaczmar,Hannah M. Knochelmann,Terry A. Day +9 more
TL;DR: Meta‐analysis shows the efficacy of PD‐1 and PD‐L1 inhibitors in HNSCC and suggests a possible difference in certain RECIST criterion between PD‐ 1 and PD-L1 inhibitor.
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Systemische Behandlung des Harnblasenkarzinoms
TL;DR: The meisten bosartigen Harnblasentumoren sind histologisch Urothelkarzinome as mentioned in this paper, and ein Viertel der Patienten weist zum Diagnosezeitpunkt bereits ein fortgeschrittenes Erkrankungsstadium auf.
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ICSBP-induced PD-L1 enhances osteosarcoma cell growth
Jee Young Sung,June Hyuk Kim,Hyun Guy Kang,Jong Woong Park,Seog Yun Park,Byung Kiu Park,Yong-Nyun Kim +6 more
TL;DR: ICSBP regulates PD-L1 expression in osteosarcoma cells, and PD- L1 knockdown combined with doxorubicin treatment could represent a strategy for controlling osteosARcoma expressing ICSBP.
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Immune-induced pneumonia in patients with advanced solid tumors treated with immunotherapy: a real-world assessment.
TL;DR: In this article , the authors investigated the CT and clinical characteristics of immunotherapy-induced pneumonitis (IIP) in patients with advanced solid tumors, including non-small-cell lung cancer, lymphoma and gastrointestinal tumors.
References
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Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
Journal ArticleDOI
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.
F. Stephen Hodi,Steven J. O'Day,David F. McDermott,R. W. Weber,Jeffrey A. Sosman,John B. A. G. Haanen,Rene Gonzalez,Caroline Robert,Dirk Schadendorf,Jessica C. Hassel,Wallace Akerley,Alfons J.M. van den Eertwegh,Jose Lutzky,Paul Lorigan,Julia Vaubel,Gerald P. Linette,David W. Hogg,Christian H. Ottensmeier,Céleste Lebbé,Christian Peschel,Ian Quirt,Joseph I. Clark,Jedd D. Wolchok,Jeffrey S. Weber,Jason Tian,Michael Yellin,Geoffrey M. Nichol,Axel Hoos,Walter J. Urba +28 more
TL;DR: Ipilimumab, with or without a gp100 peptide vaccine, as compared with gp100 alone, improved overall survival in patients with previously treated metastatic melanoma.
Journal ArticleDOI
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L. Topalian,F. Stephen Hodi,Julie R. Brahmer,Scott N. Gettinger,David Smith,David F. McDermott,John D. Powderly,Richard D. Carvajal,Jeffrey A. Sosman,Michael B. Atkins,Philip D. Leming,David R. Spigel,Scott J. Antonia,Leora Horn,Charles G. Drake,Drew M. Pardoll,Lieping Chen,William H. Sharfman,Robert A. Anders,Janis M. Taube,Tracee L. McMiller,Haiying Xu,Alan J. Korman,Maria Jure-Kunkel,Shruti Agrawal,Dan McDonald,Georgia Kollia,Ashok Kumar Gupta,Jon M. Wigginton,Mario Sznol +29 more
TL;DR: Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse-event profile does not appear to preclude its use.
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