Comprehensive Meta-analysis of Key Immune-Related Adverse Events from CTLA-4 and PD-1/PD-L1 Inhibitors in Cancer Patients
Guillermo de Velasco,Youjin Je,Dominick Bossé,Mark M. Awad,Patrick A. Ott,Raphael Brandao Moreira,Fabio A.B. Schutz,Joaquim Bellmunt,Guru Sonpavde,F. Stephen Hodi,Toni K. Choueiri +10 more
TLDR
There is substantial evidence that ICIs are associated with a small but significant increase in risk of selected all-grade irAEs and high-grade gastrointestinal and liver toxicities, and AEs should be recognized promptly as early interventions may alleviate future complications.Citations
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A rare case of Miller Fisher variant of Guillain-Barré Syndrome (GBS) induced by a checkpoint inhibitor.
TL;DR: This case of a 68-year-old male who was admitted with sudden onset of worsening neurological symptoms following immunotherapy treatment is presented, one of few in the literature and an important reminder of the potential for new immunotherapeutic agents to cause significant neurotoxic effects.
Journal ArticleDOI
Prevalence, clinical course, and predictive factors of immune checkpoint inhibitor monotherapy-associated hepatitis in Japan.
Takashi Kitagataya,Goki Suda,Kazunori Nagashima,Takehiko Katsurada,Koji Yamamoto,Megumi Kimura,Osamu Maehara,Ren Yamada,Taku Shigesawa,Kazuharu Suzuki,Akihisa Nakamura,Masatsugu Ohara,Machiko Umemura,Naoki Kawagishi,Masato Nakai,Takuya Sho,Mitsuteru Natsuizaka,Kenichi Morikawa,Koji Ogawa,Shunsuke Ohnishi,Yoshito Komatsu,Hiroo Hata,Satoshi Takeuchi,Takashige Abe,Jun Sakakibara-Konishi,Takanori Teshima,Akihiro Homma,Naoya Sakamoto +27 more
TL;DR: Although ICI may cause immune‐related adverse events (irAE) in various organs, including the liver, the prevalence and predictive factors of irAE have not been clarified.
Journal ArticleDOI
Immune-related Adverse Events in Cancer Patients.
Daniel J. Pallin,Christopher W. Baugh,Michael A. Postow,Jeffrey M. Caterino,Timothy B. Erickson,Gary H. Lyman +5 more
TL;DR: This narrative review summarizes the biology, pathophysiology, and adverse events associated with checkpoint inhibitors and CAR-T cells and provides a rational approach to management.
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Occurrences and Outcomes of Immune Checkpoint Inhibitors-Induced Vitiligo in Cancer Patients: A Retrospective Cohort Study
TL;DR: An overall picture of ICI-induced vitiligo in daily medical practice on a large number of pharmacovigilance observations of case patients is provided, and the data suggest that the resolution of pembrolizumab- or nivolumAB-induced Vitiligo could be a marker of disease progression.
Journal ArticleDOI
Checkpoint inhibitor-induced fulminant myocarditis, complete atrioventricular block and myasthenia gravis—a case report
Antonio Portolés Hernández,Mariola Blanco Clemente,Daniel Escribano García,Rocío Velasco Calvo,Beatriz Núñez García,Juan Francisco Oteo Dominguez,Clara Salas Antón,Miriam Méndez García,Javier Segovia Cubero,Fernando Dominguez +9 more
TL;DR: A 48-year-old woman with a history of progressive thymoma who developed complete atrioventricular block associated with fulminant myocarditis and myasthenia gravis 2 weeks after starting treatment with pembrolizumab is presented.
References
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Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.
F. Stephen Hodi,Steven J. O'Day,David F. McDermott,R. W. Weber,Jeffrey A. Sosman,John B. A. G. Haanen,Rene Gonzalez,Caroline Robert,Dirk Schadendorf,Jessica C. Hassel,Wallace Akerley,Alfons J.M. van den Eertwegh,Jose Lutzky,Paul Lorigan,Julia Vaubel,Gerald P. Linette,David W. Hogg,Christian H. Ottensmeier,Céleste Lebbé,Christian Peschel,Ian Quirt,Joseph I. Clark,Jedd D. Wolchok,Jeffrey S. Weber,Jason Tian,Michael Yellin,Geoffrey M. Nichol,Axel Hoos,Walter J. Urba +28 more
TL;DR: Ipilimumab, with or without a gp100 peptide vaccine, as compared with gp100 alone, improved overall survival in patients with previously treated metastatic melanoma.
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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L. Topalian,F. Stephen Hodi,Julie R. Brahmer,Scott N. Gettinger,David Smith,David F. McDermott,John D. Powderly,Richard D. Carvajal,Jeffrey A. Sosman,Michael B. Atkins,Philip D. Leming,David R. Spigel,Scott J. Antonia,Leora Horn,Charles G. Drake,Drew M. Pardoll,Lieping Chen,William H. Sharfman,Robert A. Anders,Janis M. Taube,Tracee L. McMiller,Haiying Xu,Alan J. Korman,Maria Jure-Kunkel,Shruti Agrawal,Dan McDonald,Georgia Kollia,Ashok Kumar Gupta,Jon M. Wigginton,Mario Sznol +29 more
TL;DR: Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse-event profile does not appear to preclude its use.
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