Comprehensive Meta-analysis of Key Immune-Related Adverse Events from CTLA-4 and PD-1/PD-L1 Inhibitors in Cancer Patients
Guillermo de Velasco,Youjin Je,Dominick Bossé,Mark M. Awad,Patrick A. Ott,Raphael Brandao Moreira,Fabio A.B. Schutz,Joaquim Bellmunt,Guru Sonpavde,F. Stephen Hodi,Toni K. Choueiri +10 more
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TLDR
There is substantial evidence that ICIs are associated with a small but significant increase in risk of selected all-grade irAEs and high-grade gastrointestinal and liver toxicities, and AEs should be recognized promptly as early interventions may alleviate future complications.Citations
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Hypoparathyroidism: An Uncommon Complication Associated With Immune Checkpoint Inhibitor Therapy
TL;DR: A case of hypoparathyroidism induced by immune checkpoint drugs is reported, highlighting the need for awareness of this emerging complication.
Journal ArticleDOI
Nivolumab-induced hepatitis: A rare side effect of an immune check point inhibitor.
TL;DR: A woman who was treated for recurrent renal cell carcinoma presented with hepatitis and later presented with massive upper gastrointestinal bleeding secondary to gastroduodenal ulcers and subsequently developed acute tubular necrosis and passed from the complications.
Journal ArticleDOI
Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata sensitizes prostate cancer cells in vitro and in vivo.
Suvranil Ghosh,Naibedya Dutta,Pinaki Banerjee,Rahul L. Gajbhiye,Hossainoor Rahaman Sareng,Prachi Kapse,Srabani Pal,Lyudmila G. Burdelya,Narayan Chandra Mandal,V. Ravichandiran,Ashish Bhattacharjee,Gopal C. Kundu,Andrei V. Gudkov,Mahadeb Pal +13 more
TL;DR: In this paper, a polyphenol-rich fraction of Bergenia ligulata (PFBL), a plant used in Indian traditional and folk medicine for its anti-inflammatory and antineoplastic properties, was investigated for prostate cancer.
Journal ArticleDOI
Left ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity.
Angela Y. Higgins,Amit Arbune,Aaron Soufer,Elio Ragheb,Jennifer M. Kwan,Jérôme Lamy,Mariana L. Henry,Jason Cuomo,Ahmad Charifa,Cesia Gallegos,Sarah C. Hull,Jessica Shank Coviello,Anna S. Bader,Dana C. Peters,Steffen Huber,Hamid Mojibian,Albert J. Sinusas,Harriet M. Kluger,Lauren A. Baldassarre +18 more
TL;DR: In this article, the authors identified patients referred for CMR evaluation of ICI cardiotoxicity from September 2015 through September 2019, and assessed structural and functional parameters, feature tracking (FT) left ventricular and atrial strain, T2- weighted ratios and quantitative late gadolinium enhancement (LGE).
Journal ArticleDOI
Recent advances in immune checkpoint therapy in non-small cell lung cancer and opportunities for nanoparticle-based therapy
Mohammad-Javad Sanaei,Atieh Pourbagheri-Sigaroodi,Vahid Kaveh,Hassan Abolghasemi,Seyed H. Ghaffari,Majid Momeny,Davood Bashash +6 more
TL;DR: In this article, a comprehensive review of nanoparticle-based immune checkpoint therapy for non-small cell lung cancer (NSCLC) is presented, including their efficacy and safety profile.
References
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Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
Journal ArticleDOI
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.
F. Stephen Hodi,Steven J. O'Day,David F. McDermott,R. W. Weber,Jeffrey A. Sosman,John B. A. G. Haanen,Rene Gonzalez,Caroline Robert,Dirk Schadendorf,Jessica C. Hassel,Wallace Akerley,Alfons J.M. van den Eertwegh,Jose Lutzky,Paul Lorigan,Julia Vaubel,Gerald P. Linette,David W. Hogg,Christian H. Ottensmeier,Céleste Lebbé,Christian Peschel,Ian Quirt,Joseph I. Clark,Jedd D. Wolchok,Jeffrey S. Weber,Jason Tian,Michael Yellin,Geoffrey M. Nichol,Axel Hoos,Walter J. Urba +28 more
TL;DR: Ipilimumab, with or without a gp100 peptide vaccine, as compared with gp100 alone, improved overall survival in patients with previously treated metastatic melanoma.
Journal ArticleDOI
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L. Topalian,F. Stephen Hodi,Julie R. Brahmer,Scott N. Gettinger,David Smith,David F. McDermott,John D. Powderly,Richard D. Carvajal,Jeffrey A. Sosman,Michael B. Atkins,Philip D. Leming,David R. Spigel,Scott J. Antonia,Leora Horn,Charles G. Drake,Drew M. Pardoll,Lieping Chen,William H. Sharfman,Robert A. Anders,Janis M. Taube,Tracee L. McMiller,Haiying Xu,Alan J. Korman,Maria Jure-Kunkel,Shruti Agrawal,Dan McDonald,Georgia Kollia,Ashok Kumar Gupta,Jon M. Wigginton,Mario Sznol +29 more
TL;DR: Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse-event profile does not appear to preclude its use.
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