Comprehensive Meta-analysis of Key Immune-Related Adverse Events from CTLA-4 and PD-1/PD-L1 Inhibitors in Cancer Patients
Guillermo de Velasco,Youjin Je,Dominick Bossé,Mark M. Awad,Patrick A. Ott,Raphael Brandao Moreira,Fabio A.B. Schutz,Joaquim Bellmunt,Guru Sonpavde,F. Stephen Hodi,Toni K. Choueiri +10 more
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TLDR
There is substantial evidence that ICIs are associated with a small but significant increase in risk of selected all-grade irAEs and high-grade gastrointestinal and liver toxicities, and AEs should be recognized promptly as early interventions may alleviate future complications.Citations
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Immune-related adverse events of checkpoint inhibitors.
Manuel Ramos-Casals,Julie R. Brahmer,Margaret K. Callahan,Margaret K. Callahan,Alejandra Flores-Chávez,Niamh M. Keegan,Munther A. Khamashta,Olivier Lambotte,Xavier Mariette,Aleix Prat,Maria E. Suarez-Almazor +10 more
TL;DR: This Primer by Ramos-Casals and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of immune-related adverse events and should be prescribed carefully to reduce the potential of short-term and long-term complications.
Journal ArticleDOI
Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis.
Yucai Wang,Shouhao Zhou,Shouhao Zhou,Fang Yang,Xinyue Qi,Xin Wang,Xiaoxiang Guan,Xiaoxiang Guan,Chan Shen,Narjust Duma,Jesus Vera Aguilera,Ashish V. Chintakuntlawar,Katharine A. Price,Julian R. Molina,Lance C. Pagliaro,Thorvardur R. Halfdanarson,Axel Grothey,Axel Grothey,Svetomir N. Markovic,Grzegorz S. Nowakowski,Stephen M. Ansell,Michael L. Wang +21 more
TL;DR: Different PD-1 and PD-L1 inhibitors appear to have varying treatment-related adverse events; a comprehensive summary of the incidences of treatment- related adverse events in clinical trials provides an important guide for clinicians.
Journal ArticleDOI
Management of Immunotherapy-Related Toxicities, Version 1.2019.
John A. Thompson,Bryan J. Schneider,Julie R. Brahmer,Stephanie Andrews,Philippe Armand,Shailender Bhatia,Lihua E. Budde,Luciano J. Costa,Marianne Davies,David Dunnington,Marc S. Ernstoff,Matthew J. Frigault,Brianna Hoffner,Christopher J. Hoimes,Mario E. Lacouture,Frederick L. Locke,Matthew A. Lunning,Nisha Mohindra,Jarushka Naidoo,Anthony J. Olszanski,Olalekan O. Oluwole,Sandip Pravin Patel,Sunil Reddy,Mabel Ryder,Bianca Santomasso,Scott Shofer,Jeffrey A. Sosman,Momen M. Wahidi,Yinghong Wang,Alyse Johnson-Chilla,Jillian L. Scavone +30 more
TL;DR: The content featured in this issue is an excerpt of the recommendations for managing toxicity related to immune checkpoint blockade and a review of existing evidence.
Journal ArticleDOI
Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis
Shrujal S. Baxi,Shrujal S. Baxi,Annie Yang,Renee L. Gennarelli,Niloufer Khan,Ziwei Wang,Lindsay M. Boyce,Deborah Korenstein +7 more
TL;DR: Organ specific immune-related adverse events are uncommon with anti-PD-1 drugs but the risk is increased compared with control treatments, and general adverse events related to immune activation are largely similar.
Journal ArticleDOI
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC)
Ezra E.W. Cohen,R. Bryan Bell,Carlo Bifulco,Barbara Burtness,Maura L. Gillison,Kevin J. Harrington,Quynh-Thu Le,Nancy Y. Lee,Rom Leidner,Rebecca L. Lewis,Lisa Licitra,Hisham Mehanna,Loren K. Mell,Adam Raben,Andrew G. Sikora,Ravindra Uppaluri,Fernanda Whitworth,Dan P. Zandberg,Robert L. Ferris +18 more
TL;DR: An expert committee formed by the Society for Immunotherapy of Cancer formed an expert committee tasked with generating consensus recommendations for emerging immunotherapies, including appropriate patient selection, therapy sequence, response monitoring, adverse event management, and biomarker testing serve as a foundation to assist clinicians’ understanding of the role of immunotherAPies.
References
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The risk of rash associated with ipilimumab in patients with cancer: a systematic review of the literature and meta-analysis
TL;DR: There is a significant risk of developing rash in patients with cancer receiving ipilimumab andadequate monitoring and early intervention are recommended to prevent decreased quality of life and inconsistent dosing.
Journal ArticleDOI
Ipilimumab-induced acute severe colitis treated by infliximab
Cécile Pagès,Jean Marc Gornet,Gentiane Monsel,Matthieu Allez,Philippe Bertheau,Martine Bagot,Céleste Lebbé,Manuelle Viguier +7 more
TL;DR: Because more patients are being treated with CTLA-4 blockade, management of ipilimumab-induced colitis requires further studies, and its use in metastatic melanoma raises questions of its possible impact on the evolution of cancer.
Journal ArticleDOI
Pneumonitis associated with mTOR inhibitors therapy in patients with metastatic renal cell carcinoma: Incidence, radiographic findings and correlation with clinical outcome
Donnette A. Dabydeen,Jyothi P. Jagannathan,Nikhil H. Ramaiya,Katherine M. Krajewski,Fabio A.B. Schutz,Daniel C. Cho,Ivan Pedrosa,Toni K. Choueiri +7 more
TL;DR: Preliminary data suggest that pneumonitis may be a marker of stable disease by RECIST and therefore, of therapeutic benefit in patients with mRCC treated with either temsirolimus or everolimus.
Journal ArticleDOI
Challenges in Coding Adverse Events in Clinical Trials: A Systematic Review
TL;DR: There is a lack of evidence that coding of adverse events is a reliable, unbiased and reproducible process, and the increase in categories has made detecting adverse events harder, potentially compromising safety.
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