Comprehensive Meta-analysis of Key Immune-Related Adverse Events from CTLA-4 and PD-1/PD-L1 Inhibitors in Cancer Patients
Guillermo de Velasco,Youjin Je,Dominick Bossé,Mark M. Awad,Patrick A. Ott,Raphael Brandao Moreira,Fabio A.B. Schutz,Joaquim Bellmunt,Guru Sonpavde,F. Stephen Hodi,Toni K. Choueiri +10 more
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TLDR
There is substantial evidence that ICIs are associated with a small but significant increase in risk of selected all-grade irAEs and high-grade gastrointestinal and liver toxicities, and AEs should be recognized promptly as early interventions may alleviate future complications.Citations
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Immune-related adverse events with PD-1 versus PD-L1 inhibitors: a meta-analysis of 8730 patients from clinical trials
TL;DR: In this article, a trial-level meta-analysis was conducted to investigate differences in immune-related adverse event (irAE) profiles between anti-PD-1/PD-L1 antibodies.
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Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Progress, Challenges, and Prospects
Shengjie Tang,Chao Qin,Haiyang Hu,Tao Liu,Yiwei He,Haiyan Guo,H. Yan,Jun Yi Zhang,Shou-Bai Tang,Haining Zhou +9 more
TL;DR: In this paper , the authors describe clinical trials using ICI immunotherapies for NSCLC treatment, the available data on clinical efficacy, and the emerging evidence regarding biomarkers.
Journal ArticleDOI
Immunotherapy-induced endocrinopathies: assessment, management and monitoring:
TL;DR: The mechanism of action of checkpoint inhibitors is explored and the expected endocrine adverse events and typical presentations are detailed, and the effect of high-dose glucocorticoids therapy to treat nonendocrine adverseEvents is discussed.
Journal ArticleDOI
Oral immune-related adverse events associated with PD-1 inhibitor therapy: A case series.
Muhammad Ali Shazib,Muhammad Ali Shazib,Sook-Bin Woo,Sook-Bin Woo,Herve Y. Sroussi,Herve Y. Sroussi,Ingrid Carvo,Nathaniel S. Treister,Nathaniel S. Treister,Arwa M. Farag,Arwa M. Farag,Jonathan D. Schoenfeld,Robert I. Haddad,Nicole R. LeBoeuf,Alessandro Villa,Alessandro Villa +15 more
TL;DR: Patients receiving PD-1 inhibitors may develop oral irAEs characterized by lichenoid lesions, ulcers or EM, and topical and systemic steroids appear to be effective in managing oral lesions although the severity ofirAEs may necessitatePD-1 inhibitor therapy dose modification.
Journal ArticleDOI
M2-Like TAMs Function Reversal Contributes to Breast Cancer Eradication by Combination Dual Immune Checkpoint Blockade and Photothermal Therapy.
Wenrong Zhao,Xiaochun Hu,Wenhui Li,Ruihao Li,Jinjin Chen,Lulu Zhou,Sufeng Qiang,Wenjing Wu,Shuo Shi,Chunyan Dong +9 more
TL;DR: In this paper, a stimuli-responsive multifunctional nanoplatform (ZIF-PQ-PDA-AUN) is built, which can promote the infiltration of T lymphocytes in addition to ablating tumor cells and further boost both the innate and adaptive immune reactions by cutting off PD-L1 and CD47 signals, respectively.
References
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Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
Journal ArticleDOI
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.
F. Stephen Hodi,Steven J. O'Day,David F. McDermott,R. W. Weber,Jeffrey A. Sosman,John B. A. G. Haanen,Rene Gonzalez,Caroline Robert,Dirk Schadendorf,Jessica C. Hassel,Wallace Akerley,Alfons J.M. van den Eertwegh,Jose Lutzky,Paul Lorigan,Julia Vaubel,Gerald P. Linette,David W. Hogg,Christian H. Ottensmeier,Céleste Lebbé,Christian Peschel,Ian Quirt,Joseph I. Clark,Jedd D. Wolchok,Jeffrey S. Weber,Jason Tian,Michael Yellin,Geoffrey M. Nichol,Axel Hoos,Walter J. Urba +28 more
TL;DR: Ipilimumab, with or without a gp100 peptide vaccine, as compared with gp100 alone, improved overall survival in patients with previously treated metastatic melanoma.
Journal ArticleDOI
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L. Topalian,F. Stephen Hodi,Julie R. Brahmer,Scott N. Gettinger,David Smith,David F. McDermott,John D. Powderly,Richard D. Carvajal,Jeffrey A. Sosman,Michael B. Atkins,Philip D. Leming,David R. Spigel,Scott J. Antonia,Leora Horn,Charles G. Drake,Drew M. Pardoll,Lieping Chen,William H. Sharfman,Robert A. Anders,Janis M. Taube,Tracee L. McMiller,Haiying Xu,Alan J. Korman,Maria Jure-Kunkel,Shruti Agrawal,Dan McDonald,Georgia Kollia,Ashok Kumar Gupta,Jon M. Wigginton,Mario Sznol +29 more
TL;DR: Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse-event profile does not appear to preclude its use.
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