Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction.
Ying Ying Wong,Alice Moon,Ruth Duffin,Adeline Barthet-Barateig,Hedda A. Meijer,Michael J. Clemens,Cornelia H. de Moor +6 more
TLDR
It is confirmed that cordycepin reduces the length of poly(A) tails, with some mRNAs being much more sensitive than others, and it is concluded that many of the reported biological effects of cordyCEpin are likely to be due to its effects on mTOR and AMPK signaling.About:
This article is published in Journal of Biological Chemistry.The article was published on 2010-01-22 and is currently open access. It has received 140 citations till now. The article focuses on the topics: Cordycepin & AMPK.read more
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The amazing potential of fungi: 50 ways we can exploit fungi industrially
Kevin D. Hyde,Jianchu Xu,Jianchu Xu,Sylvie Rapior,Rajesh Jeewon,Saisamorn Lumyong,Allen Grace Niego,Allen Grace Niego,Pranami D. Abeywickrama,Janith V. S. Aluthmuhandiram,Rashika S. Brahamanage,Siraprapa Brooks,Amornrat Chaiyasen,K. W. Thilini Chethana,Putarak Chomnunti,Clara Chepkirui,Boontiya Chuankid,Nimali I. de Silva,Mingkwan Doilom,Mingkwan Doilom,Mingkwan Doilom,Craig B. Faulds,Eleni Gentekaki,Venkat Gopalan,Pattana Kakumyan,Dulanjalee Harishchandra,Hridya Hemachandran,Sinang Hongsanan,Anuruddha Karunarathna,Anuruddha Karunarathna,Samantha C. Karunarathna,Sehroon Khan,Jaturong Kumla,Ruvishika S. Jayawardena,Jian-Kui Liu,Ning-Guo Liu,Thatsanee Luangharn,Allan Patrick G. Macabeo,Diana S. Marasinghe,Dan Meeks,Peter E. Mortimer,Peter E. Mortimer,Peter Mueller,Sadia Nadir,Sadia Nadir,Karaba N. Nataraja,Sureeporn Nontachaiyapoom,Meghan O’Brien,Watsana Penkhrue,Chayanard Phukhamsakda,Uma Shaanker Ramanan,Achala R. Rathnayaka,Resurreccion B. Sadaba,Birthe Sandargo,Binu C. Samarakoon,Danushka S. Tennakoon,Ramamoorthy Siva,Wasan Sriprom,Trichur S. Suryanarayanan,Kanaporn Sujarit,Nakarin Suwannarach,Thitipone Suwunwong,Benjarong Thongbai,Naritsada Thongklang,De-Ping Wei,S. Nuwanthika Wijesinghe,Jake Winiski,Jiye Yan,Erandi Yasanthika,Marc Stadler +69 more
TL;DR: This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology and provides a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.
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Tissue invasion and metastasis: Molecular, biological and clinical perspectives.
Wen Guo Jiang,Andrew James Sanders,Masaru Katoh,H. Ungefroren,Frank Gieseler,Mark E. Prince,Sarah K. Thompson,Massimo Zollo,Daniela Spano,P. Dhawan,Daniel Sliva,Pochi R. Subbarayan,Malancha Sarkar,Kanya Honoki,Hiromasa Fujii,Alexandros G. Georgakilas,Amedeo Amedei,Elena Niccolai,Amr Amin,S. Salman Ashraf,Lin Ye,William G. Helferich,Xujuan Yang,Chandra S. Boosani,Gunjan Guha,Maria Rosa Ciriolo,Katia Aquilano,Sophie Chen,Asfar S. Azmi,W N Keith,Alan Bilsland,Dipita Bhakta,Dorota Halicka,Somaira Nowsheen,Francesco Pantano,Daniele Santini +35 more
TL;DR: This review lists the disruption of E-cadherin and tight junctions, key signaling pathways, including urokinase type plasminogen activator (uPA), phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene (PI3K/AKT), focal adhesion kinase (FAK), β-catenin/zinc finger E-box binding homeobox 1 (ZEB
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Cordycepin: a bioactive metabolite with therapeutic potential.
TL;DR: This extensive review covers various molecular aspects of cordycepin interactions with its recognized cellular targets and proposes the development of novel therapeutic strategies for cancer treatment.
Journal ArticleDOI
Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs
Jadd R. Shelton,Xiao Lu,Joseph A. Hollenbaugh,Jong Hyun Cho,Franck Amblard,Raymond F. Schinazi +5 more
TL;DR: This review focuses on the chemical synthesis and biology of anticancer nucleoside, nucleotide, and base analogs that are FDA-approved and in clinical development since 2000 and explores analog syntheses as well as improved and scale-up syntheses.
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Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry
Dilani D. De Silva,Sylvie Rapior,Enge Sudarman,Marc Stadler,Jianchu Xu,S. Aisyah Alias,Kevin D. Hyde,Kevin D. Hyde +7 more
TL;DR: This review compile the information on bioactive structure-elucidated metabolites from macrofungi discovered over the last decade and highlight their unique chemical diversity and potential benefits to novel drug discovery.
References
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Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells
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AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
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