Development of Anterior Cingulate Functional Connectivity from Late Childhood to Early Adulthood
A. M. Clare Kelly,Adriana Di Martino,Lucina Q. Uddin,Zarrar Shehzad,Dylan G. Gee,Philip T. Reiss,Daniel S. Margulies,F. Xavier Castellanos,Michael P. Milham +8 more
TLDR
The findings demonstrate the utility of FC for the study of developing functional organization and suggest that measures of FC may provide a quantitative index of brain maturation in healthy subjects and those with neurodevelopmental disorders.Abstract:
Human cerebral development is remarkably protracted. Although microstructural processes of neuronal maturation remain accessible only to morphometric post-mortem studies, neuroimaging tools permit the examination of macrostructural aspects of brain development. The analysis of resting-state functional connectivity (FC) offers novel possibilities for the investigation of cerebral development. Using seed-based FC methods, we examined the development of 5 functionally distinct cingulate-based intrinsic connectivity networks (ICNs) in children (n 5 14, 10.6 6 1.5 years), adolescents (n 5 12, 15.4 6 1.2) and young adults (n514, 22.4 6 1.2). Children demonstrated a more diffuse pattern of correlation with voxels proximal to the seed region of interest (ROI) (‘‘local FC’’), whereas adults exhibited more focal patterns of FC, as well as a greater number of significantly correlated voxels at long distances from the seed ROI. Adolescents exhibited intermediate patterns of FC. Consistent with evidence for different maturational time courses, ICNs associated with social and emotional functions exhibited the greatest developmental effects. Our findings demonstrate the utility of FC for the study of developing functional organization. Moreover, given that ICNs are thought to have an anatomical basis in neuronal connectivity, measures of FC may provide a quantitative index of brain maturation in healthy subjects and those with neurodevelopmental disorders.read more
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Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268
Journal ArticleDOI
Toward discovery science of human brain function
Bharat B. Biswal,Maarten Mennes,Xi-Nian Zuo,Suril Gohel,Clare Kelly,Steve M. Smith,Christian F. Beckmann,Jonathan S. Adelstein,Randy L. Buckner,Stan Colcombe,Anne Marie Dogonowski,Monique Ernst,Damien A. Fair,Michelle Hampson,Matthew J. Hoptman,James S. Hyde,Vesa Kiviniemi,Rolf Kötter,Shi-Jiang Li,Ching Po Lin,Mark J. Lowe,Clare E. Mackay,David J. Madden,Kristoffer Hougaard Madsen,Daniel S. Margulies,Helen S. Mayberg,Katie L. McMahon,Christopher S. Monk,Stewart H. Mostofsky,Bonnie J. Nagel,James J. Pekar,Scott Peltier,Steven E. Petersen,Valentin Riedl,Serge A.R.B. Rombouts,Bart Rypma,Bradley L. Schlaggar,Sein Schmidt,Rachael D. Seidler,Greg J. Siegle,Christian Sorg,Gao Jun Teng,Juha Veijola,Arno Villringer,Martin Walter,Lihong Wang,Xu Chu Weng,Susan Whitfield-Gabrieli,Peter C. Williamson,Christian Windischberger,Yu-Feng Zang,Hong Ying Zhang,F. Xavier Castellanos,F. Xavier Castellanos,Michael P. Milham +54 more
TL;DR: The 1000 Functional Connectomes Project (Fcon_1000) as discussed by the authors is a large-scale collection of functional connectome data from 1,414 volunteers collected independently at 35 international centers.
Journal ArticleDOI
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
TL;DR: It is shown that five different neurodegenerative syndromes cause circumscribed atrophy within five distinct, healthy, human intrinsic functional connectivity networks, and a direct link between intrinsic connectivity and gray matter structure is discovered.
Journal ArticleDOI
Intrinsic Functional Connectivity As a Tool For Human Connectomics: Theory, Properties, and Optimization
Koene R. A. Van Dijk,Trey Hedden,Archana Venkataraman,Karleyton C. Evans,Sara W. Lazar,Randy L. Buckner +5 more
TL;DR: The brevity and robustness of fcMRI positions it as a powerful tool for large-scale explorations of genetic influences on brain architecture and how it can be combined with HARDI techniques to support the emerging field of human connectomics.
Journal ArticleDOI
Functional brain networks develop from a "local to distributed" organization
Damien A. Fair,Alexander L. Cohen,Jonathan D. Power,Nico U.F. Dosenbach,Jessica A. Church,Francis M. Miezin,Bradley L. Schlaggar,Steven E. Petersen +7 more
TL;DR: Over development, the organization of multiple functional networks shifts from a local anatomical emphasis in children to a more “distributed” architecture in young adults, and it is argued that this “local to distributed” developmental characterization has important implications for understanding the development of neural systems underlying cognition.
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