DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells
Rino Kimura,Nobuyuki Takahashi,Shan Lin,Tsuyoshi Goto,Kaeko Murota,Rieko Nakata,Hiroyasu Inoue,Teruo Kawada +7 more
TLDR
It is suggested that DHA can inhibit the secretion of TG from intestinal epithelial cells via PPARα activation, which attenuates postprandial hyperlipidemia.About:
This article is published in Journal of Lipid Research.The article was published on 2013-12-01 and is currently open access. It has received 39 citations till now. The article focuses on the topics: Intestinal mucosa & Postprandial.read more
Citations
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Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system.
Min-Ji Kim,Tsuyoshi Goto,Rina Yu,Kunitoshi Uchida,Makoto Tominaga,Makoto Tominaga,Yuriko Kano,Nobuyuki Takahashi,Teruo Kawada +8 more
TL;DR: Fish oil intake can induce UCP1 expression in classical brown and beige adipocytes via the SNS, thereby attenuating fat accumulation and ameliorating lipid metabolism.
Journal ArticleDOI
Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes.
TL;DR: This review will highlight recent discoveries related to dietary fat absorption with an emphasis on the presence, synthesis, and metabolism of CLDs within this process.
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Dgat1 and Dgat2 regulate enterocyte triacylglycerol distribution and alter proteins associated with cytoplasmic lipid droplets in response to dietary fat
TL;DR: Results support a model where Dgat1 and Dgat2 function coordinately to regulate the process of dietary fat absorption by preferentially synthesizing TAG for incorporation into distinct subcellular TAG pools in enterocytes.
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Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity.
Mercedes Dávalos-Salas,Magdalene K. Montgomery,Camilla M. Reehorst,Rebecca Nightingale,Irvin Ng,Holly Anderton,Sheren Al-Obaidi,Analia Lesmana,Cameron M. Scott,Paul Ioannidis,Hina Kalra,Shivakumar Keerthikumar,Lars Tögel,Angela Rigopoulos,Sylvia J. Gong,David S. Williams,Prusoth Yoganantharaja,Kim S. Bell-Anderson,Suresh Mathivanan,Yann Gibert,Scott W. Hiebert,Andrew M. Scott,Andrew M. Scott,Matthew J. Watt,John M. Mariadason,John M. Mariadason +25 more
TL;DR: It is demonstrated that intestine-specific deletion of HdAC3 (Hdac3 IKO ) protects mice from diet induced obesity and identifies intestinal HDAC3 as a potential therapeutic target for preventing obesity and related diseases.
References
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TL;DR: The latest developments in the PPAR field are presented, with particular emphasis on the physiological function ofPPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.
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TL;DR: In this cohort of initially healthy women, nonfasting triglyceride levels were associated with incident cardiovascular events, independent of traditional cardiac risk factors, levels of other lipids, and markers of insulin resistance; by contrast, fasting triglycerides showed little independent relationship.
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The Epidemiology of Obesity
TL;DR: It is likely that a gene-environment interaction, in which genetically susceptible individuals respond to an environment with increased availability of palatable energy-dense foods and reduced opportunities for energy expenditure, contributes to the current high prevalence of obesity.
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Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state.
Josef R. Patsch,Gero Miesenböck,T. Hopferwieser,V. Mühlberger,E. Knapp,J K Dunn,Antonio M. Gotto,Wolfgang Patsch +7 more
TL;DR: It is concluded that triglycerides are independent predictors of CAD in multivariate analyses including HDL cholesterol, provided that a challenge test of triglyceride metabolism such as postprandial lipemia is used.