Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning.
TLDR
The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people hospitalized with severe COVID-19 illness has engendered considerable interest in the metabolic aspects of SARS-CoV-2-induced pathophysiology as mentioned in this paper.About:
This article is published in Cell Metabolism.The article was published on 2021-03-02 and is currently open access. It has received 145 citations till now. The article focuses on the topics: Diabetes mellitus.read more
Citations
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Clinical-Epidemiology Aspect of Inpatients With Moderate or Severe COVID-19 in a Brazilian Macroregion: Disease and Countermeasures
B. O. Silva,Wellington Francisco Rodrigues,Daniela Gomes Pires Abadia,Djalma Alexandre Alves da Silva,Leonardo E. Andrade e Silva,Chamberttan S. Desidério,Thais S. Farnesi-de-Assunção,Juliana Cristina Costa-Madeira,R.M. Barbosa,Anna V. Bernardes e Borges,Andrezza C. C. Hortolani Cunha,Loren Q. Pereira,Fernanda Rodrigues Helmo,Marcela Rezende Lemes,L. M. Barbosa,Rafael Trevisan,Malu Mateus Santos Obata,G. F. Bueno,Fabiano Vilela Mundim,A. C. M. Oliveira-Scussel,I. Borges Monteiro,Y. M. Ferreira,Guilherme Henrique Machado,Kennio Ferreira-Paim,Helio Moraes-Souza,Marcos Vinicius da Silva,Virmondes Rodrigues Junior,Carlo José Freire de Oliveira +27 more
TL;DR: It was revealed that age, presence of comorbidities, length of hospitalization, and drug treatment considerably altered COVID-19’s lethality.
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COVID-19 among health care workers at the "Instituto Autonomo Hospital Universitario de Los Andes" in Merida, Venezuela
J. M. Barboza-Vílchez,J. Quintero-Rojas,A. Sivira-Penott,L. C. Valeri-Ramírez,E. R. Rejes-Medina,C. A. Angulo-Lacruz +5 more
TL;DR: Por tanto, deben fortalecerse las estrategias de prevención generales y laborales específicas, and así limitar the diseminación del SARS-CoV-2 entre el personal, para que este se desempeñe de manera segura y efectiva.
Posted ContentDOI
Predicting COVID-19 severity using major risk factors and received vaccines
Ariel Israel,Alejandro A. Schäffer,E. E. Merzon,Ilan Green,Eli Magen,Avivit Golan-Cohen,Shlomo Vinker,Eytan Ruppin +7 more
TL;DR: A model estimating the probabilities for hospitalization and mortality according to individual risk factors and vaccine doses received could help prioritize vaccination and yet scarce medications to maximize lives saved and reduce the burden on hospitalization facilities.
Journal ArticleDOI
Association between trans fatty acids and COVID‐19: A multivariate Mendelian randomization study
Xuxu Liu,Zhiwei Du,Jing Wang,Qiang Wang,Yingying Zheng,Le Niu,Chenjun Hao,Dongbo Xue,Yingmei Zhang +8 more
TL;DR: In this paper , the causal link between genetically determined TFAs and coronavirus disease 2019 (COVID•19) was investigated, and the inverse variance weighted (IVW) method was used as the primary MR analysis, and several other methods were used as supplements.
References
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TL;DR: The data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.
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Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
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Factors associated with COVID-19-related death using OpenSAFELY.
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Y S Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more
TL;DR: A range of clinical factors associated with COVID-19-related death is quantified in one of the largest cohort studies on this topic so far and includes people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors.
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