Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning.
TLDR
The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people hospitalized with severe COVID-19 illness has engendered considerable interest in the metabolic aspects of SARS-CoV-2-induced pathophysiology as mentioned in this paper.About:
This article is published in Cell Metabolism.The article was published on 2021-03-02 and is currently open access. It has received 145 citations till now. The article focuses on the topics: Diabetes mellitus.read more
Citations
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Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2.
Ya-Nan Zhang,Zhe-Rui Zhang,Hong-Qing Zhang,Xiao-Dan Li,Jia-Qi Li,Qiu-Yan Zhang,Jing Liu,Qi Li,Cheng-Lin Deng,Zhengli Shi,Zhiming Yuan,Han-Qing Ye,Bo Zhang,Bo Zhang +13 more
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Comparing the B and T cell-mediated immune responses in patients with type 2 diabetes receiving mRNA or inactivated COVID-19 vaccines
Chi-Ho Lee,V. Gray,Jia Ming Nickolas Teo,Anthony Raymond Tam,Carol H.Y. Fong,David T W Lui,P.K.P. Pang,Kwok-Hung Chan,Ivan Hung,Kathryn C.B. Tan,Guang Sheng Ling +10 more
TL;DR: T2D influences the effectiveness of COVID-19 vaccines depending on their platform, and provides a potential mechanism for the susceptibility of developing adverse outcomes observed in patients with T2D and received either CoronaVac or just one dose of BNT162b2.
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SARS-CoV-2 fires up inflammation in adipose tissue
TL;DR: In this article , the authors highlight how SARS-CoV-2 infects adipose tissue and promotes subclinical inflammation, which is an important risk factor for severe COVID-19.
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Risk Factors for Being Seronegative following SARS-CoV-2 Infection in a Large Cohort of Health Care Workers in Denmark.
Caroline Klint Johannesen,Omid Rezahosseini,Mikkel Gybel-Brask,Jonas H Kristensen,Rasmus Bo Hasselbalch,Mia Pries-Heje,Pernille B Nielsen,Andreas Knudsen,Kamille Fogh,Jakob B Norsk,Ove Andersen,Ove Andersen,Claus J. Jensen,Christian Torp-Pedersen,Christian Torp-Pedersen,Jørgen Rungby,Sisse B. Ditlev,Ida Hageman,Rasmus Mogelvang,Ram B. Dessau,Erik Elgaard Sørensen,Lene Holm Harritshøj,Fredrik Folke,Fredrik Folke,Curt Sten,Maria Elizabeth Engel Møller,Frederik Neess Engsig,Henrik Ullum,Charlotte Sværke Jørgensen,Sisse R. Ostrowski,Henning Bundgaard,Kasper Iversen,Thea Kølsen Fischer,Susanne Dam Nielsen +33 more
TL;DR: In this paper, the authors investigated the risk factors associated with seronegative following PCR-confirmed SARS-CoV-2 infection in health care workers in the capital region of Denmark.
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SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis
Jun-yi Zhu,Guang-Fa Wang,Xiaohu Huang,Hangnoh Lee,Jin-Gu Lee,Penghua Yang,Joyce van de Leemput,Wei-Lun Huang,Maureen A. Kane,Peixin Yang,Zhe Han +10 more
TL;DR: In this article , the authors demonstrate interaction of virus Nsp6 with host proteins of the MGA/MAX complex (MGA, PCGF6 and TFDP1), which shifts the balance towards MYC/MAX and activates glycolysis-with similar findings in mouse cardiomyocytes.
References
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TL;DR: The data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.
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Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
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Factors associated with COVID-19-related death using OpenSAFELY.
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Y S Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more
TL;DR: A range of clinical factors associated with COVID-19-related death is quantified in one of the largest cohort studies on this topic so far and includes people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors.
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