scispace - formally typeset
Open AccessJournal ArticleDOI

Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning.

Daniel J. Drucker
- 02 Mar 2021 - 
- Vol. 33, Iss: 3, pp 479-498
TLDR
The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people hospitalized with severe COVID-19 illness has engendered considerable interest in the metabolic aspects of SARS-CoV-2-induced pathophysiology as mentioned in this paper.
About: 
This article is published in Cell Metabolism.The article was published on 2021-03-02 and is currently open access. It has received 145 citations till now. The article focuses on the topics: Diabetes mellitus.

read more

Citations
More filters
Journal ArticleDOI

Female gender is associated with long COVID syndrome: a prospective cohort study

- 01 Apr 2022 - 
TL;DR: In this article , the authors explored the association between female gender and long COVID syndrome, defined as persistence of physical and/or psychological symptoms for more than 4 weeks after recovery from acute COVID-19 disease.
Journal ArticleDOI

Female gender is associated with “long COVID” syndrome: a prospective cohort study

Francesca Bai, +23 more
- 09 Nov 2021 - 
TL;DR: In this article, the authors explored the association between female gender and long COVID syndrome, defined as persistence of physical and/or psychological symptoms for more than 4 weeks after recovery from acute COVID-19 disease.
Journal ArticleDOI

Initial observations on age, gender, BMI and hypertension in antibody responses to SARS-CoV-2 BNT162b2 vaccine.

Raul Pellini, +28 more
- 04 Jun 2021 - 
TL;DR: In this paper, the antibody titre changes in correlation with age, gender, BMI and hypertension were analyzed in a group of 248 healthcare workers after the second dose of BNT162b2 vaccine.
Journal ArticleDOI

Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2.

Moritz Reiterer, +27 more
- 02 Nov 2021 - 
TL;DR: In this article, a screen of glucoregulatory hormones revealed lower levels of adiponectin in patients with acute respiratory distress syndrome (ARDS) and COVID-19 status.
Journal ArticleDOI

Immune cell-mediated features of non-alcoholic steatohepatitis.

Thierry Huby, +1 more
- 05 Nov 2021 - 
TL;DR: In this paper, the authors discuss current concepts related to the role of immune cells in the onset and progression of NASH, and a better understanding of the mechanisms by which immune cells contribute to NASH pathogenesis should aid the design of innovative drugs to target NASH.
References
More filters
Journal ArticleDOI

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.

Tamara S Rodrigues, +44 more
- 01 Mar 2021 - 
TL;DR: This work shows that inflammasomes are activated in response to SARS-CoV-2 infection in vitro and in COVID-19 patients, contributing to the exacerbated inflammatory response, impacting disease progression and clinical outcome.
Journal ArticleDOI

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

Ana Campos Codo, +43 more
- 01 Sep 2020 - 
TL;DR: Targeting HIF-1α-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival, and may have great therapeutic potential for the development of novel drugs to treat COVID-19.
Journal ArticleDOI

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.

Liuliu Yang, +38 more
- 02 Jul 2020 - 
TL;DR: It is found that human pancreatic beta cells and liver organoids are highly permissive to SARS-CoV-2 infection, further validated using adult primary human islets and adult hepatocyte and cholangiocyte organoids.
Journal ArticleDOI

Glycemic Characteristics and Clinical Outcomes of COVID-19 Patients Hospitalized in the United States.

Bruce W. Bode, +6 more
- 09 May 2020 - 
TL;DR: This retrospective observational study of laboratory-confirmed COVID-19 adults evaluated glycemic and clinical outcomes in patients with and without diabetes and/or acutely uncontrolled hyperglycemia hospitalized March 1 to April 6, 2020, finding that patients with diabetes and or uncontrolled hyper glycemia had a longer LOS and markedly higher mortality than patients without diabetes.
Journal ArticleDOI

Obesity is associated with impaired immune response to influenza vaccination in humans

Patricia A. Sheridan, +10 more
- 01 Aug 2012 - 
TL;DR: Results suggest obesity may impair the ability to mount a protective immune response to influenza virus, and PBMCs challenged ex vivo with vaccine strain virus demonstrated that obese individuals had decreased CD8+ T-cell activation and decreased expression of functional proteins compared with healthy weight individuals.
Related Papers (5)

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, +28 more
- 24 Jan 2020 - 

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes.

Lihua Zhu, +43 more
- 02 Jun 2020 - 

COVID-19 and diabetes mellitus: from pathophysiology to clinical management.

Soo Lim, +3 more
- 01 Jan 2021 - 

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann, +13 more
- 16 Apr 2020 - 

Factors associated with COVID-19-related death using OpenSAFELY.

Elizabeth A. Williamson, +29 more
- 08 Jul 2020 -