Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning.
TLDR
The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people hospitalized with severe COVID-19 illness has engendered considerable interest in the metabolic aspects of SARS-CoV-2-induced pathophysiology as mentioned in this paper.About:
This article is published in Cell Metabolism.The article was published on 2021-03-02 and is currently open access. It has received 145 citations till now. The article focuses on the topics: Diabetes mellitus.read more
Citations
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Proceedings ArticleDOI
Experimental model of sars cov-2 in young syrian hamsters for preclinical studies
TL;DR: In this paper , the authors showed that COVID-19-infected young Syrian hamsters showed clinical signs of COVID19 infection with moderate severity, without an increase in the main biomarkers of ARDS.
Journal ArticleDOI
Time-varying association of acute and post-acute COVID-19 with new-onset diabetes mellitus among hospitalized and non-hospitalized patients
Orna Reges,Tsafnat Test,Moshe Hoshen,Assi Cicurel,Walid Saliba,Philip Greenland,Dror Dicker,Gil Lavie +7 more
TL;DR: In this paper , the authors used Stratified Cox proportional hazards models to evaluate the occurrence of new DM in relation to COVID-19 infection in different time frames, from each landmark date until end of study.
Journal ArticleDOI
GRP78, a Novel Host Factor for SARS-CoV-2: The Emerging Roles in COVID-19 Related to Metabolic Risk Factors
TL;DR: In this article , the authors explore the emerging and potential roles of GRP78 in SARS-CoV-2 infection and discuss the association with COVID-19 risks and symptoms.
Journal ArticleDOI
Response to Letter to Editor by Dr Rohan Magoon entitled ‘Glycemic control and COVID-19 outcomes: the missing metabolic players’
K. Zhan,X. Zhang,Bo Wang,Xiaoyu Fang,S Yang,Hong Jia,L. Y. Li,Guo qiang Cao,K. Zhang,X. N. Ma +9 more
TL;DR: Response to Letter to Editor by Dr Rohan Magoon entitled ‘Glycemic control and COVID-19 outcomes: the missing metabolic players'
Journal ArticleDOI
Delirium in hospitalized COVID-19 patients: Predictors and implications for patient outcome
Vera Wilke,Mihály Sulyok,Maria-Ioanna Stefanou,Vivien Richter,Benjamin Bender,Ulrike Ernemann,U. Ziemann,Nisar P. Malek,K. Kienzle,Constantin Klein,Stefan Bunk,Siri Goepel,Annerose Mengel +12 more
TL;DR: In this article , the authors evaluated the incidence and risk factors of delirium in hospitalized COVID-19 patients, along with its impact on clinical outcome, and found that the strongest predictors for the occurrence of Delirium were blood urea nitrogen (minimal depth value), age (MD: 3.33), age, gender, disease severity (as per the highest WHO grading reached during admission), laboratory parameters for infection and renal function, and presence of comorbidities.
References
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TL;DR: The data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.
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Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
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Factors associated with COVID-19-related death using OpenSAFELY.
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Y S Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more
TL;DR: A range of clinical factors associated with COVID-19-related death is quantified in one of the largest cohort studies on this topic so far and includes people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors.
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Factors associated with COVID-19-related death using OpenSAFELY.
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Y S Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more