Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning.
TLDR
The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people hospitalized with severe COVID-19 illness has engendered considerable interest in the metabolic aspects of SARS-CoV-2-induced pathophysiology as mentioned in this paper.About:
This article is published in Cell Metabolism.The article was published on 2021-03-02 and is currently open access. It has received 145 citations till now. The article focuses on the topics: Diabetes mellitus.read more
Citations
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A Calculator for COVID-19 Severity Prediction Based on Patient Risk Factors and Number of Vaccines Received
Ariel Israel,Alejandro A. Schäffer,E. E. Merzon,Ilan Green,Eli Magen,Avivit Golan-Cohen,Shlomo Vinker,Eytan Ruppin +7 more
TL;DR: A model estimating the probabilities for hospitalization and mortality according to individual risk factors and vaccine doses received could help prioritize vaccination and yet scarce medications to maximize lives saved and reduce the burden on hospitalization facilities.
Journal ArticleDOI
The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19
Francesca Cinti,Saverio Cinti +1 more
TL;DR: This mini-review aims to retrace the adipose organ history from physiology to physiopathology, to provide therapeutic perspectives for the prevention and treatment of its two main related diseases, mainly obesity and type 2 diabetes and to summarize the most recent discoveries linking adipose tissue to COVID-19.
Journal ArticleDOI
ACE2 polymorphisms impact COVID-19 severity in obese patients
Nour Jalaleddine,Amal Bouzid,Mahmood Y. Hachim,Narjes Saheb Sharif-Askari,Bassam Mahboub,Abiola Senok,Rabih Halwani,Rifat Hamoudi,Saba Al Heialy +8 more
TL;DR: In this article , the expression of angiotensin converting enzyme 2 (ACE2), the main receptor for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is enhanced in obese individuals.
Journal ArticleDOI
Towards Goals to Refine Prophylactic and Therapeutic Strategies Against COVID-19 Linked to Aging and Metabolic Syndrome.
TL;DR: In this paper, the authors examined the prevalence and molecular mechanisms underlying enhanced risk of COVID-19 in elderly people and individuals with metabolic syndrome (MetS), which is primarily derived from obesity-induced systemic chronic low-grade inflammation with numerous complications, including type 2 diabetes mellitus.
Journal ArticleDOI
Multifaceted entrancing role of glucose and its analogue, 2-deoxy-D-glucose in cancer cell proliferation, inflammation, and virus infection.
Sananda Dey,Nensina Murmu,Tanushree Mondal,Ishita Saha,Soumendranath Chatterjee,Rahul Manna,Subhash Haldar,Sandeep Kumar Dash,Tapasree Roy Sarkar,Biplab Giri +9 more
TL;DR: 2-DG as mentioned in this paper is a modified form of D-glucose, that shows anticancer, anti-inflammatory, and anti-viral effects, and it is converted into 2-deoxy-D-GLucose-6-phosphate with the help of hexokinase.
References
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TL;DR: The data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.
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Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
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Factors associated with COVID-19-related death using OpenSAFELY.
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Y S Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more
TL;DR: A range of clinical factors associated with COVID-19-related death is quantified in one of the largest cohort studies on this topic so far and includes people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors.
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