Diagnosing COVID-19: The Disease and Tools for Detection
Buddhisha Udugama,Pranav Kadhiresan,Hannah N Kozlowski,Ayden Malekjahani,Matthew Osborne,Vanessa Y C Li,Hongmin Chen,Samira Mubareka,Samira Mubareka,Jonathan B. Gubbay,Warren C. W. Chan +10 more
TLDR
Diagnostic and surveillance technologies for SARS-CoV-2 and their performance characteristics are described and point-of-care diagnostics that are on the horizon are described to encourage academics to advance their technologies beyond conception.Abstract:
COVID-19 has spread globally since its discovery in Hubei province, China in December 2019. A combination of computed tomography imaging, whole genome sequencing, and electron microscopy were initially used to screen and identify SARS-CoV-2, the viral etiology of COVID-19. The aim of this review article is to inform the audience of diagnostic and surveillance technologies for SARS-CoV-2 and their performance characteristics. We describe point-of-care diagnostics that are on the horizon and encourage academics to advance their technologies beyond conception. Developing plug-and-play diagnostics to manage the SARS-CoV-2 outbreak would be useful in preventing future epidemics.read more
Citations
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Coronavirus Disease 2019–COVID-19
Kuldeep Dhama,Khan Sharun,Ruchi Tiwari,Shubhankar Sircar,Sudipta Bhat,Yashpal Singh Malik,Karam Pal Singh,Wanpen Chaicumpa,D. Katterine Bonilla-Aldana,Alfonso J. Rodriguez-Morales +9 more
TL;DR: Analysis of epidemiological, diagnostic, clinical, and therapeutic aspects, including perspectives of vaccines and preventive measures that have already been globally recommended to counter this pandemic virus, suggest that this novel virus has been transferred from an animal source, such as bats.
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Assay Techniques and Test Development for COVID-19 Diagnosis
Linda J. Carter,Linda V. Garner,Jeffrey Smoot,Yingzhu Li,Qiongqiong Zhou,Catherine J. Saveson,Janet M. Sasso,Anne C. Gregg,Divya J. Soares,Tiffany R. Beskid,Susan R. Jervey,Cynthia Liu +11 more
TL;DR: An ongoing theme of the COVID-19 pandemic is the need for widespread availability of accurate and efficient diagnostic testing for detection of SARS-CoV-2 and antiviral antibodies in infected indiv...
Journal ArticleDOI
Digital technologies in the public-health response to COVID-19.
Jobie Budd,Jobie Budd,Benjamin S. Miller,Erin M. Manning,Vasileios Lampos,Mengdie Zhuang,Michael Edelstein,Geraint Rees,Vincent C. Emery,Molly M. Stevens,Neil Keegan,Michael J. Short,Deenan Pillay,Ed Manley,Ingemar J. Cox,Ingemar J. Cox,David L Heymann,Anne M Johnson,Rachel A. McKendry,Rachel A. McKendry +19 more
TL;DR: The future of public health is likely to become increasingly digital, and the need for the alignment of international strategies for the regulation, evaluation and use of digital technologies to strengthen pandemic management, and future preparedness for COVID-19 and other infectious diseases is reviewed.
Journal ArticleDOI
Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles.
Parikshit Moitra,Maha Alafeef,Maha Alafeef,Maha Alafeef,Ketan Dighe,Matthew B. Frieman,Dipanjan Pan,Dipanjan Pan,Dipanjan Pan +8 more
TL;DR: A colorimetric assay based on gold nanoparticles (AuNPs), when capped with suitably designed thiol-modified antisense oligonucleotides (ASOs) specific for N-gene (nucleocapsid phosphoprotein) of SARS-CoV-2, could be used for diagnosing positive COVID-19 cases within 10 min from the isolated RNA samples.
Journal ArticleDOI
Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic.
Carsten Weiss,Marie Carrière,Laura Fusco,Laura Fusco,Ilaria Capua,Jose Angel Regla-Nava,Matteo Pasquali,James A. Scott,Flavia Vitale,Flavia Vitale,Mehmet Ünal,Cecilia Mattevi,Davide Bedognetti,Arben Merkoçi,Arben Merkoçi,Ennio Tasciotti,Ennio Tasciotti,Açelya Yilmazer,Yury Gogotsi,Francesco Stellacci,Lucia Gemma Delogu +20 more
TL;DR: Nanoimmunity by design can help to design materials for immune modulation, either stimulating or suppressing the immune response, which would find applications in the context of vaccine development for SARS-CoV-2 or in counteracting the cytokine storm, respectively.
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TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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