Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline
Andrew J. Ullmann,José María Aguado,S. Arikan-Akdagli,David W. Denning,Andreas H. Groll,Katrien Lagrou,Cornelia Lass-Flörl,Russell E. Lewis,Patricia Muñoz,Paul E. Verweij,Adilia Warris,Florence Ader,Florence Ader,Murat Akova,Maiken Cavling Arendrup,Rosemary Ann Barnes,Catherine Beigelman-Aubry,Catherine Beigelman-Aubry,Stijn Blot,Stijn Blot,Stijn Blot,Emilio Bouza,Roger J. M. Brüggemann,Dieter Buchheidt,Jacques Cadranel,Jacques Cadranel,Elio Castagnola,Arunaloke Chakrabarti,Manuel Cuenca-Estrella,George Dimopoulos,George Dimopoulos,Jesús Fortún,Jean-Pierre Gangneux,Jorge Garbino,Werner J. Heinz,Raoul Herbrecht,Claus Peter Heussel,Christopher C. Kibbler,Nikolay Klimko,Bart Jan Kullberg,Christoph Lange,Thomas Lehrnbecher,Jürgen Löffler,Olivier Lortholary,J Maertens,O. Marchetti,Jacques F. Meis,Livio Pagano,Patricia Ribaud,Malcolm Richardson,Emmanuel Roilides,Markus Ruhnke,Maurizio Sanguinetti,Donald C. Sheppard,János Sinkó,Anna Skiada,Maria J G T Vehreschild,Claudio Viscoli,Oliver A. Cornely +58 more
TLDR
Treatment duration for aspergillosis is strongly recommended based on clinical improvement, degree of immunosuppression and response on imaging, and in refractory disease, where a personalized approach considering reversal of predisposing factors, switching drug class and surgical intervention is also strongly recommended.About:
This article is published in Clinical Microbiology and Infection.The article was published on 2018-05-01 and is currently open access. It has received 848 citations till now. The article focuses on the topics: Aspergillosis & Voriconazole.read more
Citations
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Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance.
Philipp Koehler,Matteo Bassetti,Arunaloke Chakrabarti,Sharon C.-A. Chen,Sharon C.-A. Chen,Arnaldo Lopes Colombo,Martin Hoenigl,Martin Hoenigl,Nikolay Klimko,Cornelia Lass-Flörl,Rita O. Oladele,Donald C. Vinh,Li Ping Zhu,Boris Böll,Roger J. M. Brüggemann,Jean-Pierre Gangneux,John R. Perfect,Thomas F. Patterson,Thomas F. Patterson,Thorsten Persigehl,Jacques F. Meis,Jacques F. Meis,Luis Ostrosky-Zeichner,P. Lewis White,Paul E. Verweij,Paul E. Verweij,Oliver A. Cornely +26 more
TL;DR: It is proposed to be defined as possible, probable, or proven on the basis of sample validity and thus diagnostic certainty, and recommended first-line therapy is either voriconazole or isavuconazole, while azole resistance is a concern.
Journal ArticleDOI
Aspergillus fumigatus and Aspergillosis in 2019
TL;DR: The emergence of new concepts, such as nutritional immunity and the integration and rewiring of multiple fungal metabolic activities occurring during lung invasion, has helped to redefine the opportunistic pathogenesis of A. fumigatus.
Journal ArticleDOI
COVID-19 associated pulmonary aspergillosis (CAPA)—from immunology to treatment
Amir Arastehfar,Agostinho Carvalho,Frank L. van de Veerdonk,Jeffrey D. Jenks,Philipp Koehler,Robert Krause,Oliver A. Cornely,David S. Perlin,Cornelia Lass-Flörl,Martin Hoenigl +9 more
TL;DR: The treatment of CAPA is complicated by drug–drug interactions associated with broad spectrum azoles, renal tropism and damage caused by SARS-CoV-2, which may challenge the use of liposomal amphotericin B, as well as the emergence of azole-resistance.
Journal ArticleDOI
Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion.
Paul E. Verweij,Bart J. A. Rijnders,Roger J. M. Brüggemann,Elie Azoulay,Matteo Bassetti,Stijn Blot,Stijn Blot,Thierry Calandra,Cornelius J. Clancy,Cornelius J. Clancy,Oliver A. Cornely,Tom Chiller,Pieter Depuydt,Daniele Roberto Giacobbe,Nico A F Janssen,Bart Jan Kullberg,Katrien Lagrou,Cornelia Lass-Flörl,Russell E. Lewis,Peter Wei Lun Liu,Olivier Lortholary,Olivier Lortholary,Johan Maertens,Ignacio Martin-Loeches,M. Hong Nguyen,M. Hong Nguyen,Thomas F. Patterson,Thomas R. Rogers,Jeroen Schouten,Isabel Spriet,Lore Vanderbeke,Joost Wauters,Frank L. van de Veerdonk +32 more
TL;DR: The IAPA case definitions may be useful to classify patients with COVID-19-associated pulmonary aspergillosis (CAPA), while awaiting further studies that provide more insight into the interaction between Aspergillus and the SARS-CoV-2-infected lung.
Journal ArticleDOI
Invasive Aspergillosis in solid-organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice
Shahid Husain,Jose F. Camargo +1 more
TL;DR: These updated AST‐IDCOP guidelines provide information on epidemiology, diagnosis, and management of Aspergillus after organ transplantation, and the role of combination antifungals for primary therapy of IA remains controversial.
References
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Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Ben E. De Pauw,Thomas J. Walsh,J. Peter Donnelly,David A. Stevens,John E. Edwards,Thierry Calandra,Peter G. Pappas,Johan Maertens,Olivier Lortholary,Carol A. Kauffman,David W. Denning,Thomas F. Patterson,Georg Maschmeyer,Jacques Bille,William E. Dismukes,Raoul Herbrecht,William W. Hope,Christopher C. Kibbler,Bart Jan Kullberg,Kieren A. Marr,Patricia Muñoz,Frank C. Odds,John R. Perfect,Angela Restrepo,Markus Ruhnke,Brahm H. Segal,Jack D. Sobel,Tania C. Sorrell,Claudio Viscoli,John R. Wingard,Theoklis E. Zaoutis,John E. Bennett +31 more
TL;DR: These revised definitions of invasive fungal disease are intended to advance clinical and epidemiological research and may serve as a useful model for defining other infections in high-risk patients.
Journal ArticleDOI
Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis
Raoul Herbrecht,David W. Denning,David W. Denning,Thomas F. Patterson,John E. Bennett,Reginald Greene,Reginald Greene,J. W. Oestmann,Winfried V. Kern,Winfried V. Kern,Winfried V. Kern,Kieren A. Marr,Patricia Ribaud,Olivier Lortholary,Richard J. Sylvester,Robert H. Rubin,John R. Wingard,Paul Stark,Christine Durand,Denis Caillot,Eckhard Thiel,Pranatharthi H. Chandrasekar,Michael R. Hodges,Haran T. Schlamm,Peter F. Troke,Ben E. De Pauw +25 more
TL;DR: In patients with invasive aspergillosis,Initial therapy with voriconazole led to better responses and improved survival and resulted in fewer severe side effects than the standard approach of initial therapy with amphotericin B.
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Reference method for broth dilution antifungal susceptibility testing of filamentous fungi : Approved standard
John H. Rex,Clinical +1 more
TL;DR: The Quality System Approach is intended to provide a guide to the development and use of such systems in the rapidly changing environment as to ensure their effectiveness and efficiency.
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Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia
Oliver A. Cornely,Johan Maertens,Drew J. Winston,John R. Perfect,Andrew J. Ullmann,Thomas J. Walsh,David Helfgott,Jerzy Holowiecki,Dick Stockelberg,Yeow Tee Goh,Mario Petrini,Cathy Hardalo,Ramachandran Suresh,David Angulo-Gonzalez +13 more
TL;DR: In patients undergoing chemotherapy for acute myelogenous leukemia or the myelodysplastic syndrome, posaconazoles prevented invasive fungal infections more effectively than did either fluconazole or itraconazole and improved overall survival.
Journal ArticleDOI
Aspergillosis case-fatality rate: systematic review of the literature.
TL;DR: Mortality is high despite improvements in diagnosis and despite the advent of newer formulations of amphotericin B, and underlying patient conditions and the site of infection remain important prognostic factors.
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